With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
c) Preparation of Ethyl 2-(3-cvano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate [Compound of formula V]. 350.0gm of Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate, [Compound of formula IV] 123.0gm of sodium formate followed by 84.0gm of hydroxylamine hydrochloride were added to 1.4 ltr of formic acid. Reaction mixture was heated to reflux and stirred for 5hr to complete the reaction. Reaction solution was cooled to 25C. Slowly added 2.8 ltr of water at 25C. Slurry formed was stirred for about l.Ohr, filtered, washed with water and dried under vacuum to give 321.0gm of titled compound.Analytical Data- ¡¤ ^NMR (CDC13, 400 MHz) : delta 1.053-1.104 (doublet, 6H); delta 1.368-1.416 (triplet,3H); delta 2.164-2.253 (multiplet, 1H); delta 2.768 (singlet, 3H); delta 3.890-3.911 (doublet, 2H); delta 4.324-4.395 (quartet, 2H); delta 6.998-7.027 (doublet, 1H); delta 8.075-8.112 (doublet of doublet, 1H); delta 8.175-8.182 (doublet, 1H).? Mass (m/e) : 345.2, 161798-03-4
The synthetic route of 161798-03-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SANDOZ AG; LUTHRA, Parven, Kumar; KHAN, Rashid; SALUNKHE, Dadasaheb; NASIR ALI, Shafakat, Ali; WO2012/131590; (2012); A1;,
Thiazole | C3H3NS – PubChem
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