Month: September 2020

53137-27-2, 2,4-Dimethylthiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53137-27-2, 11.63 ml of ethyl 2,3-dibromopropionate was added drop-by-drop over a 15-minute period to a mixture of 15.9 g of 5B, 58.5 g of anhydrous potassium carbonate and 250 ml of acetone. The stirred mixture was refluxed for 7 hours and stored overnight. The mixture was filtered and the solvent was evaporated from the filtrate under reduced pressure (40 C.). The residue was suspended in 600 ml of ether and the mixture was washed with water, then with sodium bicarbonate solution, then dried (MgSO4). The solvent was evaporated under reduced pressure. The residue was chromatographed over silica gel using chloroform as eluent. Workup with ether and removal of the solvent gave a residue which was suspended in ethanol and placed in a freezer overnight. The solid was collected, washed with ethanol and dried to give 5, mp: 70-71 C.

The synthetic route of 53137-27-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shell Oil Company; US4205076; (1980); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

39136-63-5, 5-Phenylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of compounds 3a-3p (1equiv) and acid chloride (1equiv) in THF (?20mL), triethylamine (3equiv) was added. The mixture was stirred at room temperature for 15min followed by filtration. The solvents were evaporated and the residue was purified by column chromatography., 39136-63-5

As the paragraph descriping shows that 39136-63-5 is playing an increasingly important role.

Reference£º
Article; Khalil, Ahmed; Edwards, Jessica A.; Rappleye, Chad A.; Tjarks, Werner; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 532 – 547;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

34259-99-9, 4-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Pd(dppf)Cl2.CH2Cl2 (0.17 g, 0.0002 mole) was added to a stirred mixture of 4- bromothiazole (0.7 g, 0.004 mol), sodium carbonate ( 1.3 g, 0.012 mole) and 4-(4,4,5,5- tetramethyl-[l,3,2]dioxaborolan-2-yl)benzaldehyde (1.89 g, 0.008 mole) in a mixture of 1,4-dioxane and water (25 mL, 4: 1). The reaction mixture was heated to 80 ¡ãC and maintained for 6 hours, cooled to RT, diluted with H20 (10 mL), extracted with ethyl acetate (25 mL x 3). The organic extracts were combined, dried over anhydrous Na2S04 and concentrated under vacuum to obtain the crude 4-(thiazol-4-yl) benzaldehyde that was used as such for further reaction.

34259-99-9, 34259-99-9 4-Bromothiazole 2763218, athiazole compound, is more and more widely used in various.

Reference£º
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; SHINDE, Anil Karbhari; MOHAMMED, Abdul Rasheed; BADANGE, Rajesh Kumar; JAYARAJAN, Pradeep; BHYRAPUNENI, Gopinadh; JASTI, Venkateswarlu; (172 pag.)WO2018/42362; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-40-0,2-Bromo-4-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 1 2-Bromo-4-chlorobenzothiazole (6.21 g, 0.025 mole) and 94% sodium hydroxide (1.57 g, 0.037 mole) were added to methanol (100 c.c.), and the mixture was heated under reflux for 30 minutes. After cooling, water (100 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 4.68 g of 2-methoxy-4-chlorobenzothiazole. Yield 93.8%, purity 99.3%, m.p. 55-57 C.

3622-40-0, 3622-40-0 2-Bromo-4-chlorobenzo[d]thiazole 77178, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Sumitomo Chemical Company, Limited; US4293702; (1981); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

53572-98-8, Imidazo[2,1-b]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53572-98-8, B.3 Synthesis of carboxylic amide derivatives (general procedure II); To a solution of the respective carboxylic acid (0.030 mmol, 1.8eq) in DMF (0.25 mL) is added successively a solution of DIPEA (0.075 mmol, 4.4eq) in DMF (0.15 mL) and a solution of TBTU (0.030 mmol, 1.8eq) in DMF (0.15 mL). The obtained mixture is treated with a solution of the respective 3-aza-bicyclo[3.1.0]hexane derivative (0.017 mmol, l.Oeq, free base) in DMF (0.15 mL). The mixture is shaken over night and purified by prep. HPLC to give the respective amide derivatives.Example 65: imidazo[2,l-b]thiazole-6-carboxylic acid [(lR*,2S*,5S*)-3-(2-methyl-5-m-tolyl- thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide prepared by reaction of [(1R ,2S ,5S )-2-aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl]- (2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with imidazo[2, 1 -b]thiazole-6- carboxylic acid. LC-MS: tR = 0.84 min; [M+H]+ = 478.1.

As the paragraph descriping shows that 53572-98-8 is playing an increasingly important role.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/38251; (2008); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29927-08-0,5,6-Dimethylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: To the solution of beta-naphthol (1mmol) in methanol were added respective substituted 2-aminobenzothiazole (1mmol) and the synthesized pyrazole aldehyde31 (1mmol). The reaction mixture was refluxed for 5h. The reaction was monitored by TLC and the advantage of this method is that a solid product (white ppt) was formed in the round bottom flask after completion of the reaction. The solid compound was collected by filtration and purified by column chromatography to obtain pure pyrazole linked benzothiazole-beta-naphthol derivatives in good to excellent yields., 29927-08-0

The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nagaraju, Burri; Kovvuri, Jeshma; Kumar, C. Ganesh; Routhu, Sunitha Rani; Shareef, Md. Adil; Kadagathur, Manasa; Adiyala, Praveen Reddy; Alavala, Sateesh; Nagesh, Narayana; Kamal, Ahmed; Bioorganic and Medicinal Chemistry; vol. 27; 5; (2019); p. 708 – 720;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

55661-33-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

Example 3; 2-(2-oxo-3,3-diphenylpyrrolidin-l-yl)-7V-(l,3-thiazol-2-ylmethyl)acetamide; N1-((ethylimino)methylene)-Lambda/3,Lambda/3-dimethylpropane-l ,3-diamine hydrochloride(0.049 g, 0.254 mmol) , 2-(2-oxo-3,3-diphenylpyrrolidin-l-yl)acetic acid (Example 1C, 0.050 g, 0.169 mmol) and thiazol-2-ylmethanamine (0.021 g, 0.186 mmol) were combined and stirred together in dichloromethane (0.5 mL) at room temperature. After stirring overnight, the reaction was loaded directly onto a SF 15- 12 silica gel column (Analogix, Burlington, WI), and the title compound was eluted using a gradient of 5% to 100% ethyl acetate/hexanes over 20 minutes (flow = 30 mL/minute). 1H NMR (300 MHz, CDCl3) delta ppm 7.69 (d, J= 3.3 Hz, 1 H), 7.19-7.38 (m, 11 H), 6.77 (t, J= 5.8 Hz, 1 H), 4.67 (d, J= 5.8 Hz, 2 H), 4.09 (s, 2 H), 3.53 (t, J= 6.5 Hz, 2 H), 2.84 (t, J= 6.5 Hz, 2H); MS (ESI+) m/z 392 (M+H)+.

55661-33-1 Thiazol-2-ylmethanamine 2756507, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; BHATIA, Pramila, A.; DOHERTY, George, A.; DRIZIN, Irene; MACK, Helmut; PERNER, Richard, J.; STEWART, Andrew, O.; ZHANG, Qing Wei; WO2010/39947; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2942-23-6,2,7-Dichlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

In a nitrogen atmosphere 2,7-dichlorobenzo[d]thiazole (10.0 g, 49.3mmol) and (9-phenyl-9H-carbazol-3-yl)boronic acid(28.3 g, 98.6 mmol) was added to 300 ml of dioxane, stirred and refluxed. Then potassium carbonate (27.2 g, 197.1 mmol)Was dissolved in 50 ml of water and stirred sufficiently, followed by bis(tri-tertiary-butylphosphine)palladium (1.0 g, 4 mol%) Was added. After the reaction for 12 hours, the temperature was reduced to room temperature, the organic layer and the water layer were separated, and then the organic layer was distilled under reduced pressure.After distillate was extracted with chloroform and water, the organic layer was dried using magnesium sulfate. After drying the organic layer, compound 1 (13.4 g, 44%) was prepared through recrystallization of ethyl acetate., 2942-23-6

The synthetic route of 2942-23-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG Chem, Ltd.; Jeong Min-u; Lee Dong-hun; Jang Bun-jae; Lee Jeong-ha; Han Su-jin; Park Seul-chan; Hwang Seong-hyeon; (37 pag.)KR2020/6503; (2020); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

General procedure: 5.1.5 2-(1-(4-Fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide (7a) To a solution of 6a (2.00 g, 5.98 mmol), EDCI (1.50 g, 7.82 mmol) and iPr2NEt (2.67 mL, 15.64 mmol) in N,N-dimethylformamide (80 mL) was added HOBt (1.00 g, 7.40 mmol). The reaction mixture was stirred at ambient temperature for 15 min, followed by addition of 3-(aminomethyl)pyridine (0.73 mL, 7.16 mmol). After stirring for 17 h at ambient temperature, the reaction mixture was diluted with ethyl acetate (300 mL) and sequentially washed with water, saturated NaHCO3 solution, water and brine. The organic solution was dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo, and the residue was crystallized from ethyl acetate and hexanes to yield 7a as an off-white solid (1.93 g, 76%), mp 178-180 C (ethyl acetate/hexanes); By a similar procedure as described for 7a, 7h was obtained as an off-white solid (0.17g, 66%). Mp 189-190C (ethyl acetate/hexanes); 1H NMR (300MHz, CDCl3) delta 8.25 (s, 1H), 7.74 (br s, 1H), 7.40-7.31 (m, 3H), 7.06-6.97 (m, 2H), 6.78 (t, J=5.4Hz, 1H), 4.97 (s, 2H), 4.92 (d, J=5.4Hz, 2H), 2.67 (s, 3H); MS (ES+) m/z 431.1 (M+1), 55661-33-1

55661-33-1 Thiazol-2-ylmethanamine 2756507, athiazole compound, is more and more widely used in various.

Reference£º
Article; Sun, Shaoyi; Zhang, Zaihui; Pokrovskaia, Natalia; Chowdhury, Sultan; Jia, Qi; Chang, Elaine; Khakh, Kuldip; Kwan, Rainbow; McLaren, David G.; Radomski, Chris C.; Ratkay, Leslie G.; Fu, Jianmin; Dales, Natalie A.; Winther, Michael D.; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 455 – 465;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

41731-52-6, Ethyl 2-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-tert-butyl phenol (100 mg, 0.65 mmol) in dry THF (5 ml) was added potassium tert-butoxide (75 mg, 0.65 mmol) and the mixture was heated to reflux for 1 h. Upon cooling, the volatiles were removed in vacuo before the residue was taken up into dimethylsulf oxide (DMSO; 20 ml). Ethyl 2-chiorothiazole-4-carboxylate (prepared according to the procedure of T. R. Kelly and F. Lang, J. Org. Chem., 1996, 61 , 4623-4633; however in our EPO hands the material produced by this synthesis was a 2:1 mixture of the 2- chloro- and 5-chloro-thiazole-4-carboxylates; 130 mg, 0.67 mmol) was then added before the mixture was heated to 85 G for 16 h. Upon cooling the reaction mixture was partitioned between ethyl acetate (25 ml) and water (25 ml) and after rigorous shaking the aqueous later was separated and extracted further with ethyl acetate (3 x 25 ml). The combined organic phase was washed with brine (50 ml) and dried (MgSO4) before being concentrated in vacuo. The crude product was then purified by column chromatography (SiO2; 49:1 light petroleum-ethyl acetate to 19:1) to afford the title compound as a pale yellow oil (100 mg, 50 %). 1H NMR delta 8.20 (1 H, s), 7.20-7.27 (3 H, m), 7.01-7.05 (1 H, m), 4.31 (2 H, q), 1.31 (3 H, t) and 1.26 (9 H, s).

41731-52-6, As the paragraph descriping shows that 41731-52-6 is playing an increasingly important role.

Reference£º
Patent; PARADIGM THERAPEUTICS LTD.; WO2007/582; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica