Month: September 2020

78364-55-3, 6-Fluoro-2-hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78364-55-3

General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35272-15-2,2-Methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

1.00 g (6.99 mmol) of 2-methyl-1,3-thiazole-4-carboxylic acid was added to 3.62 g of polyphosphoricacid. 0.64 g (6.99 mmol) of hydrazinecarbothioamide was added portionwise. It was stirred for 1 h at140 ¡ãC. After cooling down to 70 ¡ãC, water (10 mL) was added dropwise. After cooling to 0 ¡ãC,aqueous ammonium hydroxide solution (25percent, 8 mL) was added till a pH value of 12 was achieved. The precipitate was collected by filtration, washed with water and dried under reduced pressure at 50 ¡ãC affording 821 mg (59percent of theory) of the title compound.?H-NMR (400MHz, DMSO-d6): 6 [ppm]= 2.69 (s, 3H), 7.33 (s, 2H), 7.96 (s, 1H). LC-MS (Method 4): R = 0.65 mm; MS (ESIpos): m/z = 199 [M+H].

35272-15-2, The synthetic route of 35272-15-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; THEDE, Kai; BENDER, Eckhard; SCOTT, William; RICHTER, Anja; ZORN, Ludwig; LIU, Ningshu; MOeNNING, Ursula; SIEGEL, Franziska; GOLZ, Stefan; HAeGEBARTH, Andrea; LIENAU, Philip; PUEHLER, Florian; BASTING, Daniel; SCHNEIDER, Dirk; MOeWES, Manfred; GEISLER, Jens; WO2015/140195; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18903-18-9,Ethyl 5-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

18903-18-9, To a solution of 2,4-dichloro-1,3,5-triazine (330.5 mg, 2.2 mmol) in dichloromethane (15 mL) at 0 C., ethyl 5-aminothiazole-4-carboxylate (345 mg, 2 mmol) was added, followed by N,N-Diisopropylethylamine (0.523 mL, 3 mmol). The reaction mixture was stirred at 0 C. for 30 minutes. Then more 2,4-dichloro-1,3,5-triazine (300 mg, 2 mmol) was added and the reaction mixture was stirred at room temperature overnight. After this time, the reaction was quenched with saturated sodium bicarbonate solution (PH?8) and extracted with dichloromethane for three times. The combined extracts were washed once with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified by flash chromatography (silica gel) to give the desired product as white solid. LCMS-ESI+ (m/z): [M+H]+ calcd for C9H9ClN5O2S: 286.7. found: 286.1.

As the paragraph descriping shows that 18903-18-9 is playing an increasingly important role.

Reference£º
Patent; Gilead Sciences, Inc.; Du, Zhimin; Guerrero, Juan A.; Kaplan, Joshua A.; Knox, JR., John E.; Lo, Jennifer R.; Mitchell, Scott A.; Naduthambi, Devan; Phillips, Barton W.; Venkataramani, Chandrasekar; Wang, Peiyuan; Watkins, William J.; Zhao, Zhongdong; (593 pag.)US2016/96827; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34259-99-9,4-Bromothiazole,as a common compound, the synthetic route is as follows.

a) 6- (Thiazol-4-yl)- 8-((2- (trimethylsilyl)ethoxy)methoxy)-3- ((2- (trimethylsilyl)ethoxy)methyl)guinazolin-4(3H)-oneA suspension of 4-bromo-thiazole (0.02 g, 0.1 mmol), (6-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-8- ((2- (trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one (0.05 g, 0.08 mmol, example 28), bis (diphenylphosphino)feffocene-palladium(II)dichloride (0.01 g, 0.01 mmol), potassium carbonate (0.03 g, 0.25 mmol) and water (0.2 ml) in dimethylformamide (1 ml) was stirred in a sealed tube at 100 ¡ãC for 2 hours and then at 80 ¡ãC overnight. Filtration and chromatography (C18 reverse phase HPLC, methanol / water (0.1percent formic acid) = 40:60 to 100:0) yielded thetitle compound as white solid (0.01 g, 18 percent). MS: mle = 506.7 [M+Hf?., 34259-99-9

34259-99-9 4-Bromothiazole 2763218, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BISSANTZ, Caterina; BONNAFOUS, Rene; BUETTELMANN, Bernd; JAKOB-ROETNE, Roland; LERNER, Christian; RUDOLPH, Markus; WO2014/102233; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

298694-30-1, 4-Bromo-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

step 2: A mixture of 4-(8-(3-(tert-butoxycarbonylamino)propyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-3-chlorophenylboronic acid (688 mg, crude), 4-bromo-2-methylthiazole (254 mg, 1.4 mmol), Pd(PPh3)4 (71 mg, 0.061 mmol) and Na2CO3 (0.5 M in water, 4 mL) in MeCN (4 mL) was stirred at 90 C. under N2 overnight. After cooling to RT, the reaction mixture was diluted with EtOAc (200 mL) and washed with aq. NaCl solution (100 mL). The organic layer was dried (MgSO4) and concentrated under reduced pressure. The residue was purified by SiO2 chromatography eluting with a PE/DCM/EtOAc gradient (3:3:2 to 1:1:2) to afford tert-butyl 3-(6-(2-chloro-4-(2-methylthiazol-4-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)propylcarbamate as yellow oil (137 mg, 63% from two steps). LCMS (ESI): m/z=503.1 [M-55]+.

298694-30-1, The synthetic route of 298694-30-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; Rudolph, Joachim; Gazzard, Lewis J.; Crawford, James J.; Ndubaku, Chudi; Drobnick, Joy; Lee, Wendy; US2015/31674; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111600-83-0,5-Bromo-4-methylthiazole,as a common compound, the synthetic route is as follows.

Compound 47b (300 mg, 1.69 mmol) under nitrogen,B2pin2 (861 mg, 3.39 mmol), Pd(dppf)Cl2 (30 mg, 0.04 mmol) and KOAc (332 mg, 3.39 mmol) were placed in a reaction flask.Add 20mL of ethylene glycol dimethyl ether,Heat to 80 C for 8 h.After the reaction was cooled to room temperature, filtered and the filtrate washed with water, EtOAc. The combined organic phase was dried over anhydrous sodium sulfate, filtered and the solvent was distilled off under reduced pressure, purified by silica gel column chromatography to give compound 47c (400mg).

111600-83-0, As the paragraph descriping shows that 111600-83-0 is playing an increasingly important role.

Reference£º
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Zhu Jiawang; Cai Jiaqiang; Li Guiying; You Zejin; Wu Yongyong; Han Runfeng; Ge Yong; Wang Lichun; Wang Jingyi; (49 pag.)CN109928979; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

777-12-8, 6-(Trifluoromethyl)benzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-(Trifluoromethyl)benzo[d]thiazol-2-amine (6.8 g, 31.16 mmol)was dissolved in THF (60 mL) under N2. Isoamyl nitrite (8.03 g,68.55 mmol) was added dropwise and the mixture was refluxed for1.5 h. Then the mixture was poured into ice-H2O (60 mL) andextracted with EtOAc. The organic layer was washed by saturatedaqueous NaCl and dried over Na2SO4. It was then concentrated andpurified via flash chromatography on silica gel to get 6 g (Yield43.2%) of 6-(trifluoromethyl)benzo[d]thiazole (21n) as a yellow oil.ES-LCMS m/z: 204.0 (MH).

777-12-8, The synthetic route of 777-12-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cao, Hengyi; Zhu, Guangya; Sun, Lin; Chen, Ge; Ma, Xinxin; Luo, Xiao; Zhu, Jidong; European Journal of Medicinal Chemistry; vol. 183; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56012-38-5,(2-Methylthiazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

Step 6: Intermediate 5-h: To a solution of intermediate 5-g (1.0 g, 105.0 mmol) and intermediate 5-d (352 mg, 2.73 mmol) in THF (20 ml) were sequentially added triphenylphosphine (1.07 g, 4.1 mmol) and DIAD (796 p1, 4.1 mmol) at room temperature and the reaction was then stirred at room temperature for 1 hour. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided intermediate 5-h as yellow oil., 56012-38-5

56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; PHARMASCIENCE, INC.; LAURENT, Alain; ROSE, Yannick; WO2014/29007; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

62266-82-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62266-82-4,6-Bromobenzo[d]thiazol-2(3H)-one,as a common compound, the synthetic route is as follows.

tert-butyl 4-[(6-bromo-2-oxo-l ,3-benzothiazol-3(2H)-yl)methyl]piperidine-l- carboxylate (11-1) , ,To a round bottom flask was added 6-bromo-l,3-benzothiazol-2(3H)-one (0.300 g, 1.304 mmol), tert-butyl 4-(hydroxymethyl)piperidine-l -carboxylate (0.365 g, 1.695 mmol), triphenylphosphine (0.455 g, 1.695 mmol), diisopropyl (E)-diazene-l,2-dicarboxylate (DIAD) (0.330 mL, 1.695 mmol), and NMP (5 mL). The reaction mixture was then permitted to stir at room temperature for two hours. The crude reaction mixture was then diluted with methanol, filtered and concentrated. Purification of crude reaction mixture by reverse phasechromatography (Waters Sunfire MSC18, 30% acetonitrile / 0.1% trifluoroacetic acid / water? 100% acetonitrile / 0.1 % trifluoroacetic acid / water) fer/-butyl 4-[(6-bromo-2-oxo-l,3- benzothiazol-3(2H)-yl)methyl]piperidine-l -carboxylate (11-1) as a tan solid. HRMS (M+H)+: observed = 427.0691 , calculated – 427.0686.

62266-82-4 6-Bromobenzo[d]thiazol-2(3H)-one 188444, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LAYTON, Mark, E.; KELLY, Michael, J.; WO2011/137046; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6436-59-5,Ethyl 2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

6436-59-5, 476 ml of a 1.2 molar solution of DIBAH in toluene is slowly added in drops at -75 C. under nitrogen to a solution that consists of 60 g of 2-methylthiazole-4-carboxylic acid ethyl ester in 1070 ml of methylene chloride. It is stirred for 2 more hours. Then, 150 ml of isopropanol, and then 230 ml of water are slowly added in drops to it, the cold bath is removed and stirred vigorously at 25 C. for 2 more hours. The precipitate that is produced is suctioned off and rewashed with ethyl acetate. The filtrate is concentrated by evaporation in a vacuum, and the residue that is thus obtained is purified by chromatography on silica gel. 35.6 g of the title compound is obtained with hexane/ether 1:1 as a colorless oil.1H-NMR (CDCl3): delta=2.8 (3H), 8.05 (1H), 10.0 (1H) ppm.

6436-59-5 Ethyl 2-methylthiazole-4-carboxylate 293353, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Schering, AG; US7001916; (2006); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica