Month: September 2020

913836-22-3, Methyl 5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

913836-22-3, To a stirred solution of methyl 5-bromo-1 ,3-thiazole-4-carboxylate (5.00 g, 22.52 mmol) in THF (80 mL) was added an aq. solution of LiOH.H20 (2.70 g, 1 12.58 mmol) in H20 (20 mL). The reaction mixture was stirred at room temperature for 18 h. DCM (50 mL) and H2O (20 mL) were then added and the reaction mixture acidified to pH~2 with 2 M aqueous HCI, followed by extraction with DCM (3 chi 20 mL). The combined organic extracts were washed with brine (20 mL), dried over MgSCU, filtered and concentrated under reduced pressure to give 5-bromo-1 ,3-thiazole-4-carboxylic acid (3.09 g, 66 % yield) as a yellow solid, which was used without further purification. LC-MS (Method D) 208.3/210.3 [M+H]+; RT 1.36 min

The synthetic route of 913836-22-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; REDX PHARMA PLC; STOKES, Neil; (163 pag.)WO2017/46603; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

121-66-4, 5-Nitro-2-aminothiazole (1 eq)And triethylamine (1.2 eq) were dissolved in CH 2 Cl 2,Chloroacetyl chloride (1.2 eq) was added dropwise at 0 C,After the addition was completed, the reaction was continued for 5h,The reaction was checked by TLC, leaving no residue of the starting material and stopping the reaction.To the reaction mixture were added 100 ml of distilled water, the aqueous phase was extracted three times with CH 2 Cl 2 (3 ¡Á 100 ml), the organic phase was washed twice with saturated NaCl (2 ¡Á 100 ml), dried over anhydrous magnesium sulfate and then concentrated by evaporation to obtain a crude product. The crude product was purified by column chromatography on silica gel (methylene chloride: methanol = 150: 1, v: v) to give pure yellow solid in 82% yield.

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Patent; Shandong University; Hu Wei; Li Xun; Wang Chuandong; Li Xing; Wang Yan; Wu Yibo; Lu Di; Wu Hao; Zhang Yunxi; (8 pag.)CN106588813; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.440100-94-7,2-Bromothiazole-5-carbonitrile,as a common compound, the synthetic route is as follows.

2) 2-Bmothiazole-5-carbonitrile (955 mg, 5.05 mmol) obtained in (1) and diisopropylethylamine (1.80 mL, 10.1 mmol) were dissolved in 1,4-dioxane (20 mL). To the solution was added 1,2-amino-2-methylpropane (1.10 mL, 10.1 mmol) under ice-cooling, and the mixture was allowed to react at room temperature overnight. After the reaction mixture was concentrated, the residue was purified by silica gel column chromatography (chloroform/methanol=10/1) to obtain the title compound (895 mg, 4.57 mmol).yield: 90%<1>H NMR (CDCl3) delta (ppm): 7.64 (1H, s), 3.15 (2H, s), 1.21 (6H, s).APCIMS (m/z): 197 (M + H)<+>

440100-94-7, The synthetic route of 440100-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KYOWA HAKKO KOGYO CO., LTD.; EP1354882; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

7210-76-6, Ethyl 2-amino-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7210-76-6

An aqueous solution of 1M-sodium hydroxide (50 ml) was added to an ethanol solution (100 ml) of ethyl 2-amino-4-methylthiazole-5-carboxylate (3.0 g) and the mixture was stirred at room temperature for 26 hours. After distilling off the solvent, acetic acid was added thereto under ice cooling (pH=5). Water was added thereto, the resultant mixture was stirred, and the crystal was collected by filtration. The crystal was washed with water, thereby obtaining 2-amino-4-methyl-thiazole-5-carboxylic acid (2.5 g) as a colorless solid.

7210-76-6 Ethyl 2-amino-4-methylthiazole-5-carboxylate 343747, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; TAISHO PHARMACEUTICAL CO., LTD.; US2012/220767; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

78502-71-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78502-71-3,Ethyl 2-(bromomethyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Example 7; 2-{(3-phenyl-1H-indazol-1-yl)methyl}thiazole-4-carboxylic acidSodium hydride (added with 40% mineral oil, 9 mg, manufactured by Kanto Chemical Co., Inc.) was added to a solution of 3-phenyl-1H-indazole (40 mg), which had been synthesized according to the literature (T. Edward, C., et al., Tetrahedron, 1991, 47, 9599-9620), in N,N-dimethylformamide (1 mL, manufactured by Kanto Chemical Co., Inc.) under ice cooling, and the mixture was stirred for 5 minutes at the same temperature. Subsequently, ethyl 2-bromomethylthiazole-4-carboxylate (51 mg) synthesized according to the method of the literature (K. Benno, et al., Leibigs. Ann. Chem., 1981, 4, 623-632) was added thereto, and the mixture was stirred overnight at room temperature. Water (1 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (3¡Á2 mL), washed with brine (10 mL), and dried (MgSO4). The solvent was then evaporated. The resulting residue was purified by PTLC (hexane:ethyl acetate=2:1), to give 7.2 mg of the title compound. LC-MS: HPLC retention time 4.08 minutes, m/z 336 (M+H), condition A-1.

The synthetic route of 78502-71-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASAHI KASEI PHARMA CORPORATION; US2010/29733; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

615-21-4, 20.0 g (0.12 mol) of 2-hydrazinobenzothiazole and 200 ml of N, N-dimethylformamide (DMF) were placed in a four-neck reactor equipped with a thermometer in a nitrogen stream to obtain a uniform solution . To this solution, 83.6 g (0.61 mol) of potassium carbonate and 30.8 g (0.15 mol) of 1-iodohexane were added and the whole of the mixture was stirred at 50 C. for 7 hours. After completion of the reaction, the reaction solution was cooled to 20 C., then the reaction solution was poured into 1000 ml of water and extracted with 800 ml of ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and sodium sulfate was filtered off. Ethyl acetate was distilled off from the filtrate under reduced pressure on a rotary evaporator to obtain a yellow solid. This yellow solid was purified by silica gel column chromatography (n-hexane: ethyl acetate = 75: 25) to obtain 21.0 g of compound (IIa) as a white solid (yield: 69.6%).

As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; (21 pag.)JP2016/190828; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5398-36-7,Ethyl 2-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

The free based 2-amino-thiazole-4-carboxylic acid ethyl ester (306 mg, 1.78 mmol) and CuCl (238 mg, 2.4 mmol) were suspended in conc. HC1 (8 ml) and the mixture cooled on a salt/ice bath. A pre-cooled solution of NaNO2 (166 mg, 2.4 mmol) in water (2ml) was added over a period of 10 min. The mixture was allowed to warm to room temperature over 1 h and was stirred for a further 1 h. Water was added and the aqueous layer extracted with EtOAc (3 x 10 ml). The combined EtOAc layers were washed with brine, dried (Na2SO4), filtered and the solvent removed in vacuo to give the title compound. Yield: 251 mg, 74% ; LC/MS tr 1.06 min; MS (ES+) m/z 192,194 (M+H) ; 1H NMR (250 MHz, CDC13) 5 1.41 (t, 3H), 4.43 (q, 2H), 8.08 (s, 1H)., 5398-36-7

5398-36-7 Ethyl 2-aminothiazole-4-carboxylate 73216, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; PHARMAGENE LABORATORIES LIMITED; WO2005/80367; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2933-29-1, 2-Amino-4,5,6,7-tetrahydrobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

46.3 mg (0.3 mmol) of 4,5,6,7-tetrahydrobenzo [d] thiazol-2-amine and 60 mg (0.3 mmol) of 2-bromoacetophenone were dissolved in 3 ml of ethanol and stirred in a microwave reactor at 150 C for 20 minutes. The residue was concentrated under reduced pressure and subjected to column chromatography (EtOAc: Hex = 1: 4) to obtain Compound 2f (23.6 mg, 31%).

2933-29-1, As the paragraph descriping shows that 2933-29-1 is playing an increasingly important role.

Reference£º
Patent; Chung-Ang University Industry-Academic Cooperation Foundation; Min, Kyung Hoon; Kwon, Ahra; Song, Ji Ho; (22 pag.)KR2017/23387; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 15 Preparation of Ethyl N-(4,5,6,7-Tetrahydrobenzothiazol-2-yl)carbamate 2-Amino-4,5,6,7-tetrahydrobenzothiazole (12.3 grams; 0.08 mol) dissolved in pyridine (50 ml.) was charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and addition funnel. Ethyl chloroformate (12 ml; 0.11 mol) was added dropwise to the reaction mixture with stirring and cooling. After the addition was completed the reaction mixture was allowed to warm to room temperature and stirring was continued for a period of about 1 hour. After this time the reaction mixture was poured into ice water (50 mol.) to form a precipitate. The precipitate was recovered by filtration, washed with water four times dried and recrystallized from ethanol to yield the desired product ethyl N-(4,5,6,7-tetrahydrobenzothiazol-2-yl)carbamate; (16.7 grams); melting point 182-184 C. The structure of the product was verified by infrared and NMR spectroscopy., 2933-29-1

As the paragraph descriping shows that 2933-29-1 is playing an increasingly important role.

Reference£º
Patent; Velsicol Chemical Corporation; US4319914; (1982); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160844-75-7,Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate,as a common compound, the synthetic route is as follows.

Preparation of febuxostat without isolation of intermediate ethyl-2-(3-cyano-4- isobutoxyphenyl)-4-methyl thiazole-5-carboxylate 3-cyano-4-isobutoxyphenyl boronic acid (5.0 gms/0.02283 moles), ethyl-2-bromo-4-methylthiazole-5-carboxylate (5.70 gms/0.02289 moles) and 50 ml of 2M aqueous sodium carbonate solution were charged in 75 ml toluene, followed by tetrakis (triphenyl phosphine) palladium (1.5 gms). The resultant mixture was stirred at 70- 75¡ãC for 1 hour. The reaction mass was cooled to 25¡ãC and extracted in ethyl acetate (30ml). The organic layer was washed with brine, dried over anhydrous sodium sulphate and the clear filtrate was distilled off completely.The residue was stirred in 40 ml THF under inert atmosphere. To the reaction mass, 2N NaOH (11 ml) was slowly added at 25-30¡ãC and stirred further at reflux for 5 hours. The reaction mass was cooled to 25¡ãC and filtered through celite. The reaction mass was acidified with diluted concentrated HCI. The reaction mass was further stirred for 30 minutes. The resulting solid was isolated by filtration, washed with water until a neutral pH and dried under vacuum to yield 3.3 gms of the titled compound. Efficiency: 72percent, 160844-75-7

The synthetic route of 160844-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CIPLA LIMITED; BIRARI, Dilip, Ramdas; RAO, Dharmaraj, Ramachandra; KANKAN, Rajendra, Narayanrao; CURTIS, Philip, Anthony; WO2011/73617; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica