Day: October 9, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: The solution of (15) (1 mmol) in anhydrous dichloromethane (10 mL) was supplemented with the appropriate isocyanate or isothiocyanate (1.1 mmol) and refluxed for 5 h. The solid product was washed with water and purified by re-crystallizationfrom aqueous ethanol, and air-dried to give the corresponding urea or thiourea compounds (16a-h). 5.3.2.2.2 1-isopropyl-3-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)urea (16b) 60% yield; mp = 92-94 C. IR (KBr) (numax/cm-1): 3294, 3070, 2927, 1679, 1569, 1234. 1H NMR (DMSO) (delta/ppm): 1.09 (d, J = 6.6 Hz, 6H, (CH3)2), 1.73 (br s, 4H, CH2), 2.47 (br s, 2H, CH2), 2.56 (br s, 2H, CH2), 3.75 (m, 1H, CH), 6.41 (d, J = 7.3 Hz, 1H, NH), 9.83 (br s, 1H, NH). 13C NMR (DMSO) (delta/ppm): (CH3): 22.76; (CH2): 22.04, 22.63, 22.98, 25.94; (CH): 41.23; (Cq): 141.45, 142.74, 151.97, 167.83. Anal. (C11H17N3OS) theoretical: 55.20% C, 7.16% H, 17.56% N, 13.39% S; found: 55.55% C, 7.21% H, 17.30% N, 12.99% S.

2933-29-1, 2933-29-1 2-Amino-4,5,6,7-tetrahydrobenzothiazole 18046, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Harrouche, Kamel; Renard, Jean-Francois; Bouider, Nafila; De Tullio, Pascal; Goffin, Eric; Lebrun, Philippe; Faury, Gilles; Pirotte, Bernard; Khelili, Smail; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 352 – 360;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20358-02-5,4-Bromobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

In the reaction vessel 4-bromobenzo[20358-02-5

The synthetic route of 20358-02-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; MANDAL, Mihir; TANG, Haifeng; XIAO, Li; SU, Jing; LI, Guoqing; YANG, Shu-Wei; PAN, Weidong; TANG, Haiqun; DEJESUS, Reynalda; HICKS, Jacqueline; LOMBARDO, Matthew; CHU, Hong; HAGMANN, William; PASTERNAK, Alex; GU, Xin; JIANG, Jinlong; DONG, Shuzhi; DING, Fa-Xiang; LONDON, Clare; BISWAS, Dipshikha; YOUNG, Katherine; HUNTER, David, N.; ZHAO, Zhiqiang; YANG, Dexi; WO2015/112441; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

41731-52-6, Ethyl 2-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Sodium borohydride (690 mg, 18 mmol) was added as a single portion to a solution of ethyl 2-chloro-4-thiazolecarboxylate (1.6 g, 9 mmol) in ethanol (70 ml) at 0 C., then the mix was allowed to warm to room temperature with stirring overnight. The reaction was acidified to pH 5 with IN HCl and concentrated under vacuum, then the white residue was partitioned between water (125 ml) and ethyl acetate (3*300 ml). The organic phase was washed with brine and dried (Na2SO4), then the solvents were removed. Chromatography of the residue on silica gel (15 g, eluent 15%/-30% hexane/ethyl acetate) gave 2-chloro-4-hydroxymethylthiazole (850 mg, 5.5 mmol) in 63% yield as a clear oil, 1H nmr, 4.72 (s, 2H), 7.11 (s, 1H)., 41731-52-6

The synthetic route of 41731-52-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biota Scientific Management Pty Ltd.; US7078403; (2006); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

Example 1286-Chloro-2-oxo-8-(2-oxo-2-((thiazol-2-ylmethyl)amino)ethyl)-1 ,2-dihydroquinoline- 3-carboxylic acid a) Methyl 6-chloro-2-methoxy-8-(2-oxo-2-(thiazol-2-ylmethylamino)ethyl)- quinoline-3-carboxylate[00366] Thiazol-2-yl-methylamine (104 muIota, 1 .10 mmol, 2.0 equiv.) is added to a suspension of (CO)sMoCINEt (220 mg, 0.55 mmol) in ethanol (5 mL). The resulting mixture is stirred under a nitrogen atmosphere for 2 h. Diglyme (5 mL) is added to the mixture and heated to 120 C with evaporation of ethanol. Tributylamine (144 muIota, 0.60 mmol, 1 .10 equiv.) and methyl 8-(bromomethyl)-6-chloro-2-methoxyquinoline-3- carboxylate (170 mg, 0.49 mmol, 0.9 equiv.) are added and the mixture is heated at 130 C for 2 h. The reaction mixture is filtered over kieselguhr and the filtrate is concentrated in vacuo. The residue is taken on hydromatrix and purified by flash column chromatography (silica, 1 -10% MeOH in DCM) to afford 89 mg (44%) of the title compound as a solid. 1H NMR (400 MHz, CDCI3), delta (ppm) 3.90 (s, 3H), 3.96 (s, 3H), 4.08 (s, 2H), 4.36 (d, 2H), 6.56 (br s, 1 H), 7.07-7.13 (m, 2H), 7.22-7.29 (m, 3H), 7.72 (s, 2H), 8.54 (s, 1 H). LC-MS: 399 [M+H] [35CI]., 55661-33-1

The synthetic route of 55661-33-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merz Pharma GmbH & Co. KGaA; ABEL, Ulrich; HANSEN, Angela; WOLTER, Falko Ernst; KRUEGER, Bjoern; KAUSS, Valerjans; ROZHKOVS, Jevgenijs; SEMENIHINA, Valentina; PISKUNOVA, Irena; PELSS, Juris; WO2012/164085; (2012); A1;,
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Thiazole | chemical compound | Britannica

934-34-9, Benzothiazolone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Intermediates 19-26 were prepared following literature procedures, with slight modifications [50]. A solution of 10-14 (6.6mmol) in acetone (20mL) was mixed with K2CO3 (10mmol) and stirred at room temperature for 10min. After addition of the appropriate 1-bromo-omega-chloroalkane or 1,omega-dibromoalkane (7.3mmol), the mixture was stirred for further 24h. Inorganic materials was removed by filtration, then the solvent was removed in vacuum to obtain a residue which was used without any further purification for the next step. For analytical purpose, crude 23-26 were purified by flash chromatography or by recrystallization.

934-34-9, As the paragraph descriping shows that 934-34-9 is playing an increasingly important role.

Reference£º
Article; Salerno, Loredana; Pittala, Valeria; Romeo, Giuseppe; Modica, Maria N.; Marrazzo, Agostino; Siracusa, Maria A.; Sorrenti, Valeria; Di Giacomo, Claudia; Vanella, Luca; Parayath, Neha N.; Greish, Khaled; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 162 – 172;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1452-16-0, 2-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 2.5 M solution of nBuLi (2.0 eq) in hexane was added under argon to a solution of 2,2-dimethoxyethanamine (2.0 eq) in THF at -78C. After stirring for 30 min, thiazole-2-carbonitrile (2-Im-2, 3.0 g, 1.0 eq) was added and the resulting solution was stirred at 0 C for 2h, then quenched with 20 mL of 5% MeOH in water. The volatiles were removed and 6N HC1 was added to adjust to pH=l. The acidic solution was refluxed overnight, cooled to rt then poured into a mixture of ice and aqueous a2C03. This was extracted with EtOAc and the organic layer was concentrated to give Imadazole 2. LCMS (0.01% Ammonia): 152.1 m/z (M+H)+; ?-NMR (DMSO-d6, 500MHz): delta: 13.19 (bs, 1H), 7.98 (d, 1H, J=3.0Hz), 7.82 (d, 1H, J=3.0Hz), 7.36 (s, 1H), 7.14 (s, 1H)., 1452-16-0

As the paragraph descriping shows that 1452-16-0 is playing an increasingly important role.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; GALEMMO, Robert, A., Jr.; ARTIS, Dean, Richard; YE, Xiaocong, Michael; AUBELE, Danielle, L.; TRUONG, Anh, P.; BOWERS, Simeon; HOM, Roy, K.; ZHU, Yong-Liang; NEITZ, R., Jeffrey; SEALY, Jennifer; ADLER, Marc; BEROZA, Paul; ANDERSON, John, P.; WO2011/79114; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Step A:4-bromothiazole-2-carboxylic acid (1,1.0 g, 4.8 mmol)Dissolved in ethylene glycol dimethyl ether (12mL)And water (4mL),Add 4-fluorophenylboronic acid (17, 1.0 g, 7.2 mmol)And anhydrous potassium carbonate (994 mg, 7.2 mmol),Then tetrakis(triphenylphosphine)palladium (277 mg, 0.24 mmol) was added.The resulting mixture was heated to 98 C under nitrogen for 24 hours.TLC analysis indicated the end of the reaction.The reaction solution was cooled to room temperature.Then add water (40 mL),The pH was adjusted to 2-3 with 6M hydrochloric acid.Filtered, the filter cake was dissolved in 20 mL of dichloromethane.The dichloromethane layer was washed with a saturated sodium bicarbonate solution.Divide the water layer,Adjust the pH of the water layer to 2-3,Filter the suspension,The filter cake was dried to give compound 18 (906 mg).Yield: 84.7%.

88982-82-5, 88982-82-5 4-Bromo-1,3-thiazole-2-carboxylic acid 15122065, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Zhejiang Haizheng Pharmaceutical Co., Ltd.; Wang Haibo; Zheng Xiaohe; Cai Zhengjiang; Zheng Shan; Ye Zhengchun; Ma Huidan; Lin Haiming; (54 pag.)CN108623532; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Step 1: 2-Bromo-1,3-thiazole-5-carboxamide Into a 2 L round-bottom flask was added ethyl 2-bromothiazole-5-carboxylate (50.0 g, 212 mmol), THF (500 mL) and MeOH (250 mL). To this was added concentrated ammonium hydroxide in water (590 mL) and the reaction mixture was stirred at room temperature for 4 h. The solvents were removed under reduced pressure and the crude mixture poured into a separatory funnel containing brine (1 L). The aqueous layer was extracted with EtOAc (4*500 mL) and the combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure.

41731-83-3, The synthetic route of 41731-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Isabel, Elise; Lachance, Nicolas; Leclerc, Jean-Philippe; Leger, Serge; Oballa, Renata M.; Powell, David; Ramtohul, Yeeman K.; Roy, Patrick; Tranmer, Geoffrey K.; Aspiotis, Renee; Li, Lianhai; Martins, Evelyn; US2011/301143; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

440100-94-7,440100-94-7, 2-Bromothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-bromothiazole-5-carbonitrile (200 mg, 1.05 mmol), tert-butylpiperazine-1-carboxylate (800 mg, 4.3 mmol), potassium phosphate tribasic (260 mg, 1.22mmol), palladium acetate trimer (40 mg, 0.06 mmol), tri-tert-butylphosphinetetrafluoroborate (20 mg, 0.06 mmol) in toluene (4 mL), taken in a microwave vial underargon atmosphere was irradiated for 30 min at 80 C (TLC indicated complete consumptionof starting material). The reaction mixture was diluted with water (10 mL) and extracted withEtOAc (3 x 30 mL). The combined organic extracts were washed with brine (10 mL), driedover N a2S04 and concentrated under reduced pressure. The crude product obtained waspurified by column chromatography (100-200 silica gel, 20 g, 10-30% EtOAc-Hexane) toafford tert-butyl 4-(5-cyanothiazol-2-yl)piperazine-1-carboxylate (200 mg, 64%) as a whitesolid LCMS (ESI+): m/z: 295.60 [M+Ht.

The synthetic route of 440100-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MITOBRIDGE, INC.; TAKAHASHI, Taisuke; KLUGE, Arthur; LAGU, Bharat; JI, Nan; (162 pag.)WO2018/125961; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

615-21-4, In a 4-neck reactor equipped with a thermometer, 10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 100 ml of DMF in a nitrogen stream.To this solution, 41.8 g (304 mmol) of potassium carbonate and 10.34 g (60.6 mmol) of 5-bromovaleronitrile were added and the whole of the mixture was stirred at 60 C. for 8 hours.After completion of the reaction, the reaction solution was cooled to 20 C., poured into 1000 ml of water, and extracted with 1000 ml of ethyl acetate.After drying the ethyl acetate layer with anhydrous sodium sulfate, sodium sulfate was filtered off. Ethyl acetate was distilled off under reduced pressure from the filtrate by a rotary evaporator to obtain a yellow solid.This yellow solid was purified by silica gel column chromatography (n-hexane: ethyl acetate = 60: 40)As a white solid, 6.82 g of Intermediate T was obtained (yield: 45.7%).

The synthetic route of 615-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (77 pag.)JP6191793; (2017); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica