Brief introduction of 2933-29-1

2933-29-1, 2933-29-1 2-Amino-4,5,6,7-tetrahydrobenzothiazole 18046, athiazole compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: The solution of (15) (1 mmol) in anhydrous dichloromethane (10 mL) was supplemented with the appropriate isocyanate or isothiocyanate (1.1 mmol) and refluxed for 5 h. The solid product was washed with water and purified by re-crystallizationfrom aqueous ethanol, and air-dried to give the corresponding urea or thiourea compounds (16a-h). 5.3.2.2.2 1-isopropyl-3-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)urea (16b) 60% yield; mp = 92-94 C. IR (KBr) (numax/cm-1): 3294, 3070, 2927, 1679, 1569, 1234. 1H NMR (DMSO) (delta/ppm): 1.09 (d, J = 6.6 Hz, 6H, (CH3)2), 1.73 (br s, 4H, CH2), 2.47 (br s, 2H, CH2), 2.56 (br s, 2H, CH2), 3.75 (m, 1H, CH), 6.41 (d, J = 7.3 Hz, 1H, NH), 9.83 (br s, 1H, NH). 13C NMR (DMSO) (delta/ppm): (CH3): 22.76; (CH2): 22.04, 22.63, 22.98, 25.94; (CH): 41.23; (Cq): 141.45, 142.74, 151.97, 167.83. Anal. (C11H17N3OS) theoretical: 55.20% C, 7.16% H, 17.56% N, 13.39% S; found: 55.55% C, 7.21% H, 17.30% N, 12.99% S.

2933-29-1, 2933-29-1 2-Amino-4,5,6,7-tetrahydrobenzothiazole 18046, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Harrouche, Kamel; Renard, Jean-Francois; Bouider, Nafila; De Tullio, Pascal; Goffin, Eric; Lebrun, Philippe; Faury, Gilles; Pirotte, Bernard; Khelili, Smail; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 352 – 360;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica