20485-41-0, 4-Methylthiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A mixture of 69 (250 mg, 0.81 mmol), HATU (460 mg, 1.2 mmol), dry N,N-dimethylformamide (5 mL), diisopropylethylamine (0.4 mL) and trimethylacetic acid (165 mg, 1.62 mmol) was stirred at room temperature for 12 h. The reaction mixture was poured into water (40 mL), extracted with ethyl acetate (3 x 30 mL), organic phases combined, washed with water (3 x 50 mL), a saturated aqueous solution of brine (20 mL), dried (magnesium sulfate), filtered and concentrated. The crude material was purified by Flashmaster II chromatography (eluent 0-90 percent ethyl acetate/dichloromethane). The purified material was taken up in diethyl ether (10 mL), washed with water (2 x 10 mL) to remove any trace N,N-dimethylformamide, dried (magnesium sulfate), filtered and concentrated to give 1-{4-[(4-Chloro-2-fluorophenyl)(pyridin-3-yl)methyl]piperazin-1-yl}-2,2-dimethylpropan-1-one (13) (53 mg, 17 percent) as a yellow oil.#10;, 20485-41-0
As the paragraph descriping shows that 20485-41-0 is playing an increasingly important role.
Reference£º
Article; Keenan, Martine; Alexander, Paul W.; Diao, Hugo; Best, Wayne M.; Khong, Andrea; Kerfoot, Maria; Thompson, R. C. Andrew; White, Karen L.; Shackleford, David M.; Ryan, Eileen; Gregg, Alison D.; Charman, Susan A.; Von Geldern, Thomas W.; Scandale, Ivan; Chatelain, Eric; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1756 – 1763;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica