With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.464192-28-7,2-Bromo-5-formylthiazole,as a common compound, the synthetic route is as follows.,464192-28-7
Intermediate 103 (16.34 g, 0.086 mol) was dissolved in methanol (300 mL) and cooled to 10C. Sodium borohydride (1.63 g, 0.043 mol) was added portionwise over 15 min. The cooling bath was removed and the reaction allowed to warm to room temperature and stirred for 3 hours. The solvent was evaporated. Water (100 mL) was added followed by 1N HCI (200 mL). Ethyl acetate (450 mL) was added and the phases were separated. The organic layer was washed with brine (450 mL), dried (MgS04) and concentrated to give a brown liquid. The crude product was purified by chromatography on silica, using cyclohexane-ethyl acetate (80: 20 v/v) as eluent to give the title compound. ‘H NMR (CDCI3) : 8 7.4 (1H, s), 4.82 (2H, d), 2.96 (1H, t)
The synthetic route of 464192-28-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/37818; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica