With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,78364-55-3
General procedure: Equimolar amounts of appropriate 2-hydrazinobenzothiazole1a-b, alpha-cyanoacetophenone 2a-c, and PTSA were mixed thoroughly in pestle mortar and heated on water bath for 4-5 min and then equimolar amount of appropriate trifluoromethyl beta-diketones 3a-d was added to it and mixed thoroughly. The reaction mixture was again heated 80-90 ¡ã C for 15 min on water bath. The solid was obtained by addition of aq. ethanol, filtered and crystallized from the mixture of ethanol and chloroform to give pure 4.
78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.
Reference£º
Article; Aggarwal, Ranjana; Kumar, Virender; Bansal, Anshul; Sanz, Dionisia; Claramunt, Rosa M.; Journal of Fluorine Chemistry; vol. 140; (2012); p. 31 – 37;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica