With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-78-1,2-(Chloromethyl)thiazole,as a common compound, the synthetic route is as follows.
(5- (4-Bromophenoxy) pyridin-2-yl) carbamic acid tert-butyl ester (1.460 g, 4 mmol) was dissolved in 12 mL DMFStir at room temperature, add sodium hydride (0.24g, 10mmol),After the addition was complete, the reaction was continued for 30 minutes.Then, chloromethylthiazole (1.344 g, 8 mmol) in DMF solvent (5 mL) was slowly added dropwise, and the temperature was raised to 50 C for reaction overnight.Then, 15 mL of ice water was added to the reaction, and the mixture was extracted with ethyl acetate.Combined organic phasesThe organic phase was washed with saturated brine,Dried over magnesium sulfate,Concentrated to give an oil.The oil obtained above was dissolved in 15 mL of dichloromethane.Trifluoroacetic acid (0.912g, 8mmol) was slowly added dropwise at room temperature.After the dropwise addition was completed, the mixture was stirred at 40 C and reacted overnight;The reaction was then concentrated and an aqueous potassium carbonate solution was added,Adjust the pH to 8, extract with ethyl acetate, and wash the organic phase with water.Dried, concentrated,Column chromatography [petroleum ether / ethyl acetate (v / v) = 6/4],The target compound was obtained (0.852 g, yield: 54%)., 3364-78-1
As the paragraph descriping shows that 3364-78-1 is playing an increasingly important role.
Reference£º
Patent; Dongguan Dongyangguang Pesticide Research And Development Co., Ltd.; Li Yitao; Lin Jian; Xu Junxing; Xiao Yu; Yao Wenqiang; Liu Xinshuo; (44 pag.)CN110452238; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica