With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170235-26-4,Methyl 2-bromothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
Example 76; Preparation of Compound 76A and 76B; To a suspension of NaH (60% dispersion in oil, 10 mmol, 0.48 g.) in anhydrous dioxane (5 mL) was added a solution of indazole (10 mmol, 1.18 g) in dioxane (5 ml.) and the resulting reaction was allowed to stir for 30 minutes. A solution of 2- bromo-thiazole-4-carboxylic acid methyl ester (10.0 mmol, 2.22 g) in dioxane (5 mL) was then added dropwise and the reaction mixture was heated to 100C for 4 hrs. The reaction mixture was cooled to room temperature, quenched with water, and the solution was adjusted to pH 2 using 1 N HCI. The resulting basic solution was extracted with ethyl acetate and the organic phase was washed with water and brine, dried over anhydrous sodium sulfate, then filtered and concentrated. LCMS of the resulting residue showed two peaks for the acid indicating the formation of two regioisomers (Compounds 76A and 76B). HPLC-MS RT= 1.35 and 1.45 min, mass calculated for formula CnH7N3O2S 245.03, observed LCMS m/z 246.1 (M+H)., 170235-26-4
170235-26-4 Methyl 2-bromothiazole-4-carboxylate 2763213, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; SCHERING CORPORATION; WO2008/54749; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica