Day: October 16, 2020

170961-15-6, tert-Butyl thiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To tetrahydrofuran solution (100 ml) of 47 (10.0 g, 49.9 mmol), t-butoxy potassium (6.72 g, 59.9 mmol) was added at 0C while stirring, stirred for 10 min at the same temperature, added iodomethane (4.66 ml, 74.9 mmol), and stirred for 16 hours at room temperature. The insolubles were removed by filtering the reaction mixture, and the filtrate was evaporated to dryness under reduced pressure. The residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate = 9/1), to obtain 48 (6.53 g, 61%) of colorless solid substance. mp 51?52 C, 1H NMR(500MHz, DMSO-D6)delta 1.53(9H,s),3.47(3H,s),7.25(1H,d,J=3.5Hz),7.45(1H,d,J=3.5Hz) ,IR(Neat)1734cm-1, APCI-MS m/z 215[M+H]+, 170961-15-6

The synthetic route of 170961-15-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tohoku University; EP2103611; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

72850-52-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72850-52-3,Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

2-Chloro-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester (259 mg, 1.0mmol), sodium ethoxide (23% by weight in ethanol) (0.33 ml, 1.1 mmol) and ethanol (2ml) were heated under reflux for 2 hours. The mixture was partitioned between water andethyl acetate. The organic phase was dried over magnesium sulfate and concentrated togive the product as a yellow gum (187 mg, 70% yield). ^-NMR (400 MHz, CDC13):1.36 (3H, t, Me), 1.45 (3H, t, Me), 4.35 (2H, q, CH2), 4.55 (2H, q, CH2).

As the paragraph descriping shows that 72850-52-3 is playing an increasingly important role.

Reference£º
Patent; SYNGENTA LIMITED; WO2006/24820; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3292-77-1, 2-Bromo-1-(thiazol-2-yl)ethanone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2-bromo-1-(thiazol-2-yl)ethanone (2.5 g; 12 mmol), acetonitrile (70 ml) and imidazole (1.65 g; 24 mmol) was stirred at ambient temperature for 1 hour. The mixture was evaporated to dryness and the residue partitioned between dichloromethane and water. The organic phase was separated, washed with saturated brine and evaporated to give 2-(imidazol-1-yl)-1-(thiazol-2-yl)-ethanone as a brown solid (1.17 g; 50%). MP: 109-112 C. 1H NMR (DMSO d6, 400 MHz) delta: 5.6 (2H,s); 6.85-8.1 (5H,m).

3292-77-1, 3292-77-1 2-Bromo-1-(thiazol-2-yl)ethanone 2795212, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; AstraZeneca UK Limited; Zeneca-Pharma SA; US6342765; (2002); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

348-40-3, 6-Fluorobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1,1?-Carbonyldiimidazole (12 mmol)was added to a solution of 6-(substituted)benzo[d]thiazol-2-amine (10 mmol) in dry dichloromethane (50 mL) and the reaction was stirred for 20 h at reflux conditions. The reaction mixture was cooled down to 2-8 C, filtered and washed with cold dichloromethane. The crude product was dried under reduced pressure to yield N-(6-(substituted)benzo[d]thiazol-2-yl)-1H-imidazole-1-carboxamide as a white solid (90-95%) and used in next reaction without further purification.

348-40-3, The synthetic route of 348-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hroch, Lukas; Benek, Ondrej; Guest, Patrick; Aitken, Laura; Soukup, Ondrej; Janockova, Jana; Musil, Karel; Dohnal, Vlastimil; Dolezal, Rafael; Kuca, Kamil; Smith, Terry K; Gunn-Moore, Frank; Musilek, Kamil; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3675 – 3678;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 24 Intermediate 25 (1.12g, 5.84mmol) and 5-aminothiazole-4-carboxylic acid ethyl ester (0.9g, 5.84mmol) were combined in toluene (25ml_). The mixture was stirred under a nitrogen atmosphere at 60C for 1 hour and then at room temperature for 18 hours. The mixture was partitioned between 1 M hydrochloric acid and ethyl acetate and the layers separated. The aqueous layer was extracted with ethyl acetate and the combined organic layers dried with Na2S04, filtered and concentrated in vacuo to dryness. The residue was purified by chromatography on silica eluting with 0-70% ethyl acetate/cyclohexane. The fractions containing the desired product were combined and the solvents removed by evaporation in vacuo to give Intermediate 24 (298mg) as a cream solid. LCMS (Method 2) Rt 3.09 min; m/z(M+H)+ 328, 18903-18-9

As the paragraph descriping shows that 18903-18-9 is playing an increasingly important role.

Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3855-95-6,2-Chloro-6-benzothiazolecarboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of di-tert-butyl dicarbonate (1.2 mL, 5.0 mmol) and 2-chlorobenzo[d]thiazole-6-carboxylic acid (0.53 g, 2.5 mmol) in anhydrous t-butanol (10 mL) was added dimethylaminopyridine (91 mg, 0.74 mmol) and the mixture stirred for 1 h. The reaction was concentrated under reduced pressure and purified by silica gel chromatography eluting with 0-50% EtOAc/hexanes to give Compound 1 88a (0.56 g, 84% yield) as a clear oil. LCMS = 2.22 mm using analytical method (B), 270.0 (M+H).1H NMR (400MHz, CDC13) oe 8.45 (d, J=1.5 Hz, 1H), 8.12 (dd, J8.6, 1.8 Hz, 1H), 7.97 (d, J8.6 Hz, 1H), 1.55 – 1.42 (m, 9H)., 3855-95-6

The synthetic route of 3855-95-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; JOHNSON, James A.; JIANG, Ji; KIM, Soong-Hoon; PI, Zulan; QIAO, Jennifer X.; TORA, George O.; WANG, Tammy C.; FINLAY, Heather; WO2014/11513; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-42-5,4-Methylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 18: 4-METHYL-2-HYDRAZINOBENZOTHIAZOLE To a suspension of 4-methyl-2-aminobenzothiazole (5.0 g., 0.03 mole) in 20 ml. of ethylene glycol was added 5.4 g. of 85% hydrazine hydrate (0.09 mole) and 2.75 g. (0.046 mole) acetic acid. The mixture was heated to 126C. under N2 atmosphere for 3 hours. On cooling and dilution with about 1/2 volume of water the product crystallized.

1477-42-5, As the paragraph descriping shows that 1477-42-5 is playing an increasingly important role.

Reference£º
Patent; Eli Lilly and Company; US3937714; (1976); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

78502-81-5, 5-Bromo-2-methyl-4-phenylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 27A (40 mg, 0.116 mmol), 5-bromo-2-methyl-4-phenylthiazole (59 mg, 0.232 mmol), Pd(PPh3)4(13 mg, 0.012 mmol) and K2CO3 (48 mg, 0.349 mmol) in THF (3 mL) and water (1 mL) was heated in a microwave reactor at 130 C. for 20 min. under Ar, then was cooled to rt. The reaction was diluted with water (5 mL), and extracted with EtOAc (4¡Á10 mL). The combined organic fractions were dried over MgSO4, and concentrated in vacuo to give the crude title compound. This material was used directly for the next step without further purification. LCMS, [M+H]+=392.1., 78502-81-5

The synthetic route of 78502-81-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; Shi, Yan; Cheng, Peter T.W.; Wang, Ying; Jusuf, Sutjano; Tao, Shiwei; Zhang, Hao; Wu, Shung C.; Robl, Jeffrey A.; (87 pag.)US2017/253554; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.33 2-(4-(Thiophen-2-yl)butanoyl)benzo[d]isothiazol-3(2H)-one (37) Compound 37 was prepared through 4-(2-thienyl)butyric acid, obtained a white solid in 81% yield. Mp 117.4-118.3 C. 1H NMR (400 MHz, DMSO-d6) delta 7.95 (t, J = 8.0 Hz, 2H), 7.79 (t, J = 8.0 Hz, 1H), 7.47 (t, J = 7.6 Hz, 1H), 7.33 (dd, J = 4.8, 0.8 Hz, 1H), 6.95 (dd, J = 4.8, 3.6 Hz, 1H), 6.89 (d, J = 2.8 Hz, 1H), 3.16 (t, J = 7.6 Hz, 2H), 2.91 (t, J = 7.6 Hz, 2H), 2.04-1.96 (m, 2H); 13C NMR (101 MHz, DMSO-d6) delta 173.1, 163.5, 144.5, 141.4, 135.0, 127.4, 126.5, 125.7, 125.1, 124.1, 122.5, 36.5, 28.9, 26.2. IR (KBr, cm-1): 1699, 1687. HRMS-ESI (m/z) calcd for C15H13NO3S2 [M+H+] 304.0466, found 304.0478., 2634-33-5

2634-33-5 1,2-Benzothiazol-3-one 17520, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1003-61-8, 2-Aminothiazole-5-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Amino-5-formylthiazole (11.5 g, 90 mmol) was dissolved in methanol (120 mL), and sodium borohydride (5.11 g, 135 mmol) was added thereto while cooling with ice, followed by stirring at the same temperature for 1 hour. Acetone (6 mL) and water (10 mL) were added to the reaction mixture, followed by stirring. The residue obtained by evaporating the reaction mixture under reduced pressure was purified using medium pressure silica gel flash column chromatography (methanol:chloroform=1:15), thereby giving the title compound (5.09 g, 43%) as a white solid.

1003-61-8, 1003-61-8 2-Aminothiazole-5-carbaldehyde 2737798, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; TAIHO PHARMACEUTICAL CO., LTD.; Urade, Yoshihiro; Kitade, Makoto; Yamane, Keiko; Aoki, Shinichi; Yamanaka, Hiroyoshi; US2013/165438; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica