18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 24 Intermediate 25 (1.12g, 5.84mmol) and 5-aminothiazole-4-carboxylic acid ethyl ester (0.9g, 5.84mmol) were combined in toluene (25ml_). The mixture was stirred under a nitrogen atmosphere at 60C for 1 hour and then at room temperature for 18 hours. The mixture was partitioned between 1 M hydrochloric acid and ethyl acetate and the layers separated. The aqueous layer was extracted with ethyl acetate and the combined organic layers dried with Na2S04, filtered and concentrated in vacuo to dryness. The residue was purified by chromatography on silica eluting with 0-70% ethyl acetate/cyclohexane. The fractions containing the desired product were combined and the solvents removed by evaporation in vacuo to give Intermediate 24 (298mg) as a cream solid. LCMS (Method 2) Rt 3.09 min; m/z(M+H)+ 328, 18903-18-9
As the paragraph descriping shows that 18903-18-9 is playing an increasingly important role.
Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica