With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3855-95-6,2-Chloro-6-benzothiazolecarboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of di-tert-butyl dicarbonate (1.2 mL, 5.0 mmol) and 2-chlorobenzo[d]thiazole-6-carboxylic acid (0.53 g, 2.5 mmol) in anhydrous t-butanol (10 mL) was added dimethylaminopyridine (91 mg, 0.74 mmol) and the mixture stirred for 1 h. The reaction was concentrated under reduced pressure and purified by silica gel chromatography eluting with 0-50% EtOAc/hexanes to give Compound 1 88a (0.56 g, 84% yield) as a clear oil. LCMS = 2.22 mm using analytical method (B), 270.0 (M+H).1H NMR (400MHz, CDC13) oe 8.45 (d, J=1.5 Hz, 1H), 8.12 (dd, J8.6, 1.8 Hz, 1H), 7.97 (d, J8.6 Hz, 1H), 1.55 – 1.42 (m, 9H)., 3855-95-6
The synthetic route of 3855-95-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; JOHNSON, James A.; JIANG, Ji; KIM, Soong-Hoon; PI, Zulan; QIAO, Jennifer X.; TORA, George O.; WANG, Tammy C.; FINLAY, Heather; WO2014/11513; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica