Day: October 19, 2020

1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-(5-thiazolyl)-3-cyclohexylpropan-1-ol A solution of thiazole-5-carboxaldehyde (2.31 g, 20.4 mmol) in 20 mL of in THF was added to a cold (0 C.) solution of 2-cyclohexylethylmagnesium bromide (prepared from 2-bromoethylcyclohexane (7.88 g) and magnesium turnings (1.22 g)) in 30 mL of ethyl ether and the mixture stirred 30 minutes. The cold bath was removed and the mixture stirred for 2 hours more and then quenched by the addition of 3N aqueous HCl. The solution was stirred until 2 clear phases resulted and then the layers were separated. The pH of the aqueous phase was adjusted to 4 with 2M aqueous sodium carbonate and then extracted with 3 portions of ethyl acetate. All the organic phases were combined and washed with brine, dried, filtered and concentrated. The residue was purified by column chromatography on silica gel (125 g, 50% ethyl acetate/hexanes) to provide 2.69 g (58%) of the title compound. MS (DCI, NH3): 226 (MH+); 243 (M+NH4)+.

1003-32-3, As the paragraph descriping shows that 1003-32-3 is playing an increasingly important role.

Reference£º
Patent; University of Pittsburgh; US6204293; (2001); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

911466-96-1,911466-96-1, 2-(Ethoxycarbonyl)thiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of Compound 3A (0.300 g, 1.49 mmol) was dissolved in N,N- dimethylformamide (2.98 mL), and then treated successively with PYBOP (0.854 g, 1.64 mmol), 4-methylmorpholine (0.492 mL, 4.47 mmol) and 1,2,3,4- tetrahydroquinoline (0.218 mL, 1.64 mmol). The reaction was stirred overnight at room temperature and was then slowly added to 15 mL of water, The aqueous layer was extracted with CH2CI2 (3 x 15 mL). The combined organic layer was washed with saturated aqueous NaHCO3 solution (25 mL) and brine (25 mL). The organic layer was dried over Na2SO4, filtered and concentrated. The product was purified by flash chromatography using a gradient of 0-40% ethyl acetate-hexanes to provide compound 4A (0.121 g, 26% yield).

The synthetic route of 911466-96-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2009/58730; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

72605-86-8, Methyl 2-chlorothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

72605-86-8, General procedure: A mixture of compounds 12a-c (6.5 mmol, 1.0 eq), methyl2-chlorothiazole-5-carboxylate (1.2 g, 6.5 mmol, 1.0 eq),and K2CO3 (904.0 mg, 6.5 mmol, 1.0 eq) in CH3CN(10.0 mL) was stirred at 82 C for 16 h. The mixture wasconcentrated to give the crude compounds 13-15, whichwas put into next step without further purification.

As the paragraph descriping shows that 72605-86-8 is playing an increasingly important role.

Reference£º
Article; Zhang, Jiankang; Xi, Jianjun; He, Ruoyu; Zhuang, Rangxiao; Kong, Limin; Fu, Liping; Zhao, Yanmei; Zhang, Chong; Zeng, Linghui; Lu, Jingyi; Tao, Rujia; Liu, Zhengmengtong; Zhu, Huajian; Liu, Shourong; Medicinal Chemistry Research; vol. 28; 10; (2019); p. 1633 – 1647;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

89281-44-7, 2-Methylthiazol-5-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

89281-44-7, Compound 3 was dissolved in methanol (10 mL), and then a solution of the corresponding thiazole amine in methanol (5 mL) was added to the solution. The reaction mixture was stirred at 45 C for 12 h. After the reaction was completed, which was monitored with TLC, the mixture was concentrated and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. Crude product was purified by column chromatography (ethyl acetate/petroleum ether = 8:1) to give compound 7a and 7b.

As the paragraph descriping shows that 89281-44-7 is playing an increasingly important role.

Reference£º
Article; Zheng, Min; Yao, Ting-Ting; Xu, Xiao-Jun; Cheng, Jing-Li; Zhao, Jin-Hao; Zhu, Guo-Nian; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3565 – 3568;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139670-03-4,2-Bromo-4-chlorothiazole,as a common compound, the synthetic route is as follows.

Isopropylmagnesium chloride lithium chloride complex solution (4.58 mL, 5.95 mmol) was added slowly to a suspension of 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-N-methoxy-N-methylpropanamide (784 mg, 1.983 mmol) and 2-bromo-4-chlorothiazole (Intermediate Q, step 2) (394 mg, 1.983 mmol) in THF (30 mL). The mixture was stirred at room temperature for 40 mins. The reaction mixture was quenched with saturated NH4Cl(aq) and extracted with EtOAc (2¡Á). The combined organic extracts were washed with brine, dried over sodium sulphate and evaporated under vacuum. Purification by chromatography on silica, eluting with 10-60% EtOAc/hexane afforded the title compound. [1181] 1H NMR (400 MHz, CDCl3) delta 7.79-7.59 (4H, mult), 7.51 (1H, s), 6.51 (1H, s), 4.41 (2H, t), 3.50 (2H, t), 3.41 (3H, s), 3.35 (3H, s) [1182] LC-MS Rt 1.20 mins [M+H]+ 454.0 (Method 2minLowpHv03)

139670-03-4, As the paragraph descriping shows that 139670-03-4 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPHERD, Jon; WRIGHT, Paul; US2014/171417; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20949-81-9,2-Phenylthiazole-4-carbaldehyde,as a common compound, the synthetic route is as follows.

A solution of aldehyde 5 (10 mmol), benzoylacetone 6(10 mmol), concentrated H2SO4 (0.1 mL), thiourea andmethanol (50 mL) was refluxed for 24 h. The mixture wascooled and the precipitates were collected and crystallizedfrom methanol to produce compound 7.Yield: 74%. mp:148-151C , 1HNMR (DMSO-d6) : 1.69(s,3H,CH3), 5.45 (s,1H,H4), 7.35 (s, 1H,H-thiazol), 7.45-7.82 (m, 10H, phenyl), 7.89 (bs,1H, NH), 9.20 (bs,1H, NH),13CNMR (DMSO-d6) : 16.3 (CH3-C6), 55.2 (C4-tetrahydropyrimidine), 110.3, 113.4, 127.1, 127.3, 128.1,128.2, 129.3, 129.5, 130.1, 130.3, 131.4, 133.4, 133.7, 137.8,155.2, 162.3, 170.1, 175.3, 188.4, IR (KBr) cm-1: 3317,3114, 2924, 1713, 1674, 1180. Anal. Calcd. for C21H17N3OS2: C, 64.42; H, 4.38; N, 10.73. Found: C, 64.39; H, 4.46;N,10.56.

20949-81-9, The synthetic route of 20949-81-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sharifzadeh, Mohammad; Khademi, Hamid Reza; Almasirad, Ali; Rezayan, Zahra; Ghayahbashi, Mohsen Rezayan; Amini, Mohsen; Letters in drug design and discovery; vol. 10; 9; (2013); p. 900 – 905;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

61830-21-5, Ethyl 2-amino-5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,61830-21-5

General procedure: A mixture of 2-aminothiazole derivatives 2a-h and 3a-e (1.0 mmol) and K2CO3 (4.0 mmol) was stirred at room temperature with drop-wise addition of 4-chlorobutyryl chloride (4.0 mmol) in chloroform for 48 h. The reaction mixture was monitored by TLC (using chloroform/ethyl acetate 9:1). Ammoniated water was added, and the organic layer was separated and dried over anhydrous Na2SO4, and the solvent was removed in vacuum. The resulting precipitate was crystallized from ethanol to give crystals of pure N-(thiazole-2-yl)-4-chlorobutanamide derivatives.

The synthetic route of 61830-21-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ghabbour, Hazem A.; Kadi, Adnan A.; Eltahir, Kamal E. H.; Angawi, Rihab F.; El-Subbagh, Hussein I.; Medicinal Chemistry Research; vol. 24; 8; (2015); p. 3194 – 3211;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. Hydrazone of 5-thiazolecarboxaldehyde and t-butylcarbazate Using the procedure of Example 1D, but replacing benzaldehyde with 5-thiazolecarboxaldehyde (Dondoni, et. al., Synthesis, 998(1987)), provided the desired compound., 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Abbott Laboratories; US5461067; (1995); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.394223-37-1,Benzo[d]thiazol-5-ylmethanol,as a common compound, the synthetic route is as follows.

To a mixture of compound B-188 (2.8 g, 17 mmol) in anhydrous dichloromethane (20 mL) was added manganese dioxide (14 g, 0.16 mol) at room temperature. The mixture was stirred at room temperature for 16 hours. On completion, the reaction was filtered, and the filtrate was concentrated in vacuo to give compound B-189 (2.5 g, 93% yield) as a yellow solid.

394223-37-1, As the paragraph descriping shows that 394223-37-1 is playing an increasingly important role.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-34-9,Benzothiazolone,as a common compound, the synthetic route is as follows.

General procedure: K2CO3 9.2 g, 66.6 mmol) and 1,4-dibromobutane (21.0 mL, 177.6 mmol) were added, under stirring, to a solution of benzo[d]oxazol-2(3H)-one (3.0 g, 22.2 mmol) in anhydrous DMF (30 mL). The reaction mixture was heated at 60 C for 3 h. After cooling, the reaction mixture was poured into 100 mL water and extracted with ethyl acetate (3 x 70 mL). The combined organic layers were washed with saturated aqueous NaCl and dried over sodium sulfate. The solvent was removed in vacuo, and the residue was purified by flash column chromatography (SiO2) using hexane/ethyl acetate (8:2) as eluent to give 3.6 g (62%) of 2e as a white solid. 4.2.1.3 3-(2-Bromoethyl)benzo[d]thaizol-2(3H)-one (2b) General procedure A, yield 57%, white solid. 1H NMR (400 MHz, CDCl3) delta 7.64-6.99 (m, 4H), 4.37 (t, J = 6.2, 2H), 3.82 (t, J = 6.1, 2H). 13C NMR (101 MHz, CDCl3) delta 166.07, 154.40, 142.70, 135.83, 134.62, 122.03, 120.40, 55.74, 39.59. MS (EI) m/z 258 (M++1).

934-34-9, The synthetic route of 934-34-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abdelazeem, Ahmed H.; Khan, Shabana I.; White, Stephen W.; Sufka, Kenneth J.; McCurdy, Christopher R.; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3248 – 3259;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica