With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20949-81-9,2-Phenylthiazole-4-carbaldehyde,as a common compound, the synthetic route is as follows.
A solution of aldehyde 5 (10 mmol), benzoylacetone 6(10 mmol), concentrated H2SO4 (0.1 mL), thiourea andmethanol (50 mL) was refluxed for 24 h. The mixture wascooled and the precipitates were collected and crystallizedfrom methanol to produce compound 7.Yield: 74%. mp:148-151C , 1HNMR (DMSO-d6) : 1.69(s,3H,CH3), 5.45 (s,1H,H4), 7.35 (s, 1H,H-thiazol), 7.45-7.82 (m, 10H, phenyl), 7.89 (bs,1H, NH), 9.20 (bs,1H, NH),13CNMR (DMSO-d6) : 16.3 (CH3-C6), 55.2 (C4-tetrahydropyrimidine), 110.3, 113.4, 127.1, 127.3, 128.1,128.2, 129.3, 129.5, 130.1, 130.3, 131.4, 133.4, 133.7, 137.8,155.2, 162.3, 170.1, 175.3, 188.4, IR (KBr) cm-1: 3317,3114, 2924, 1713, 1674, 1180. Anal. Calcd. for C21H17N3OS2: C, 64.42; H, 4.38; N, 10.73. Found: C, 64.39; H, 4.46;N,10.56.
20949-81-9, The synthetic route of 20949-81-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Sharifzadeh, Mohammad; Khademi, Hamid Reza; Almasirad, Ali; Rezayan, Zahra; Ghayahbashi, Mohsen Rezayan; Amini, Mohsen; Letters in drug design and discovery; vol. 10; 9; (2013); p. 900 – 905;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica