With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139670-03-4,2-Bromo-4-chlorothiazole,as a common compound, the synthetic route is as follows.
Isopropylmagnesium chloride lithium chloride complex solution (4.58 mL, 5.95 mmol) was added slowly to a suspension of 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-N-methoxy-N-methylpropanamide (784 mg, 1.983 mmol) and 2-bromo-4-chlorothiazole (Intermediate Q, step 2) (394 mg, 1.983 mmol) in THF (30 mL). The mixture was stirred at room temperature for 40 mins. The reaction mixture was quenched with saturated NH4Cl(aq) and extracted with EtOAc (2¡Á). The combined organic extracts were washed with brine, dried over sodium sulphate and evaporated under vacuum. Purification by chromatography on silica, eluting with 10-60% EtOAc/hexane afforded the title compound. [1181] 1H NMR (400 MHz, CDCl3) delta 7.79-7.59 (4H, mult), 7.51 (1H, s), 6.51 (1H, s), 4.41 (2H, t), 3.50 (2H, t), 3.41 (3H, s), 3.35 (3H, s) [1182] LC-MS Rt 1.20 mins [M+H]+ 454.0 (Method 2minLowpHv03)
139670-03-4, As the paragraph descriping shows that 139670-03-4 is playing an increasingly important role.
Reference£º
Patent; NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPHERD, Jon; WRIGHT, Paul; US2014/171417; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica