911466-96-1,911466-96-1, 2-(Ethoxycarbonyl)thiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of Compound 3A (0.300 g, 1.49 mmol) was dissolved in N,N- dimethylformamide (2.98 mL), and then treated successively with PYBOP (0.854 g, 1.64 mmol), 4-methylmorpholine (0.492 mL, 4.47 mmol) and 1,2,3,4- tetrahydroquinoline (0.218 mL, 1.64 mmol). The reaction was stirred overnight at room temperature and was then slowly added to 15 mL of water, The aqueous layer was extracted with CH2CI2 (3 x 15 mL). The combined organic layer was washed with saturated aqueous NaHCO3 solution (25 mL) and brine (25 mL). The organic layer was dried over Na2SO4, filtered and concentrated. The product was purified by flash chromatography using a gradient of 0-40% ethyl acetate-hexanes to provide compound 4A (0.121 g, 26% yield).
The synthetic route of 911466-96-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SCHERING CORPORATION; WO2009/58730; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica