6436-59-5, Ethyl 2-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 46 Ethyl 2-methyl-1 ,3-thiazole-4-carboxylate [6436-59-5] (5.0g, 29.2mmol) was dissolved in acetonitrile (50ml_). To this, NBS (5.7g, 32.03mmol) was added at room temperature and the mixture heated at reflux for 2 hours. To this, NBS (2.5g, 14.05mmol) was added and the mixture heated at reflux for 2 hours. To this, NBS (2.5g, 14.05mmol) was added and the mixture heated at reflux for 18 hours. The mixture was diluted with saturated sodium hydrogen carbonate solution and extracted with ethyl acetate. The organic layer was dried with MgS04, filtered and concentrated in vacuo to dryness. The residue was purified by chromatography on silica eluting with 0-50% ethyl acetate/cyclohexane. The fractions containing the desired product were combined and the solvents removed by evaporation in vacuo to give Intermediate 46 (1.58g) as a cream solid. LCMS (Method 2) Rt 2.88 min; m/z(M+H)+ 250/252, 6436-59-5
As the paragraph descriping shows that 6436-59-5 is playing an increasingly important role.
Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica