Analyzing the synthesis route of 74370-93-7

74370-93-7 4-(tert-Butyl)thiazol-2-amine 2734202, athiazole compound, is more and more widely used in various fields.

74370-93-7, 4-(tert-Butyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-(iert-butyl)thiazol-2-amine (200 mg, 1.28 mmol), and DIEA (438 muIota_, 2.56 mmol) in THF (1.5 mL) was added cyclopentanecarbonyl chloride (172 muL, 1.41 mmol). After allowing to stand at ambient temperature for 1 h, the mixture was washed with 1 N NaOH (2X2 mL), brine (2X2 mL), dried with sodium sulfate, filtered, and concentrated. Flash chromatography (0-20% hexanes/ethyl acetate) provided N-(4-tert-butyl-1 ,3-thiazol-2- yl)cyclopentanecarboxamide (286 mg, 89% yield) (A127) as a colorless solid. LCMS for C13H2oN2OS, found 253 [M+H]+., 74370-93-7

74370-93-7 4-(tert-Butyl)thiazol-2-amine 2734202, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; KEZAR LIFE SCIENCES; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MCMINN, Dustin; JOHNSON, Henry; TAUNTON, John, William; CARRASCO, Yazmin, Paulina; SHARP, Phillip, Patrick; (156 pag.)WO2019/46668; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica