With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1452-16-0,2-Cyanothiazole,as a common compound, the synthetic route is as follows.
A mixture of 5 mg iron trichloride (FeCI3), 2 g of sodium and 40 ml of t-amylalcohol is heated to 110 0C for 20 minutes before a mixture of 3.9 g of the thiazole-2-nitrile of the formula 1 and 7.82 g of 8 is added portion-wise. The reaction mixture is stirred at 1 10 0C for 3 hours before it is poured onto 6.3 g acetic acid in a water-methanol mixture (100ml/100ml). Bchner filtration and exhaustive washing with methanol affords 4.5 g of the desired 1 ,4- diketopyrrolo[3,4-c]pyrrole (DPP) derivative of the formula A-42 as dark blue powder; ESI- MS m/z (% int.): 302.15 ([M+H]+, 100%)., 1452-16-0
1452-16-0 2-Cyanothiazole 15111480, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; BASF SE; HAYOZ, Pascal; AEBISCHER, Olivier Frederic; DUeGGELI, Mathias; TURBIEZ, Mathieu G. R.; FONRODONA TURON, Marta; CHEBOTAREVA, Natalia; WO2010/115767; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica