With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42182-65-0,Benzo[d]thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.,42182-65-0
A solution of 4-(3-chloro-1,2,4-triazin-5-yl)-3-methylphenol (60 mg, 0.27 mmol), benzothiazol-2-yl-methylamine (89 mg, 0.54 mmol), pyridine (28 muL, 0.32 mmol) in anhydrous acetonitrile (0.4 mL) was stirred at 85C overnight. The solution was then concentrated and the residue was purified by preparative TLC (silica gel, dichloromethane/methanol 92/8) to give 4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol (33.8 mg, 36%) as a yellow oil. ESI-MS m/z 350 (M+H)+. 1H NMR (CDCl3), delta (ppm): 8.78 (s, 1H), 7.97 (d, J = 8.1 Hz, 1H), 7.83 (d, J = 8.1 Hz, 1H), 7.48 (t, J = 7.5 Hz, 1H), 7.39-7.31 (m, 2H), 6.77-6.75 (m, 2H), 6.56 (br s, 1H), 5.16 (s, 2H), 2.30 (s, 3H).
42182-65-0 Benzo[d]thiazol-2-ylmethanamine 350414, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; Mutabilis; EP2141164; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica