Day: October 21, 2020

173979-01-6, 4-(Tributylstannyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 63 (3-Chloro-5-thiazol-4-yl-phenyl)-(1 H-imidazol-2-yl)-methanoneA solution of Example 53 (50 mg, 0.15 mmol) in 1 ,4-dioxane (3 ml_) was stirred in a microwave reaction tube. 4-Tributylstannanyl-thiazole (62 mg, 0.165 mmol) followed by Pd(PPh3)4 (10 mg, 8.6 mumol) was added to the stirred mixture. The tube was sealed and the reaction was heated at 1200C for 30 mins. The mixture was then diluted with EtOAc (20 ml.) and washed with brine. The organic phase was then dried over Na2SO4, filtered and the solvent evaporated. The crude was triturated in dichloromethane and the collected precipitate was purified further by SiO2 chromatography (Hexanes/ EtOAc; 9:1 to 2:1 ) to give the title compound as a beige solid (10 mg, 23%). MS(ESI) m/z 289.9 (M+H)+. 1H NMR (400 MHz, DMSO-d6): 13.62 (1 H, s), 9.28 (1 H, d), 8.97 (1 H, t), 8.58 (1 H, t), 8.46 (1 H, d), 8.34 (1 H, t), 7.58 (1 H, s), 7.39 (1 H, s).

173979-01-6, The synthetic route of 173979-01-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; ASTEX THERAPEUTICS LIMITED; HOWARD, Steven; MORTENSON, Paul Neil; HISCOCK, Steven Douglas; WOOLFORD, Alison Jo-Anne; WOODHEAD, Andrew James; CHESSARI, Gianni; O’REILLY, Marc; CONGREVE, Miles Stuart; DAGOSTIN, Claudio; CHO, Young Shin; YANG, Fan; CHEN, Christine Hiu-Tung; BRAIN, Christopher Thomas; LAGU, Bharat; WANG, Yaping; KIM, Sunkyu; GRIALDES, John; LUZZIO, Michael Joseph; PEREZ, Lawrence Blas; WO2010/125402; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

79836-78-5, Ethyl 2-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Intermediate 15-a To a solution of ethyl 2-methylthiazole-5-carboxylate (5.82 g, 34.0 mmol) in THF (170 ml), cooled to 0 C, was added a 1.0M solution of LiAIH4 in THF (34.0 ml, 34.0 mmol) and the reaction was slowly warmed to room temperature and stirred overnight. Water (1.3 ml) was slowly added, followed by 15% NaOH (1.3 ml_). The solution was stirred for 2 hours at room temperature then filtered over celite. The filtrate was concentrated under reduced pressure to provide intermediate 15-a as a yellow oil., 79836-78-5

The synthetic route of 79836-78-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHARMASCIENCE, INC.; LAURENT, Alain; ROSE, Yannick; JAQUITH, James B.; WO2013/177668; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13623-11-5,2,4,5-Trimethylthiazole,as a common compound, the synthetic route is as follows.

2,4,5-trismethyl thiazole (2.5 g, 19.65 mmol), N-bromosuccinimide(10.49 g, 58.96 mmol) and benzoyl peroxide (30 mg) were dissolved in 150 ml of CCl4. Resulting mixture was stirred at 70 C for 5 h. After cooling, succinimide salt was removed by water washing and product was extracted by DCM (50 ml ¡Á 2).To this organic layer washed with brine solution and dried over Na2SO4. This product was also not stable at room temperature for long time and it was stable only at below 15 C in DCMsolvent. This crude product was also used for further synthesiswithout purification.

13623-11-5, The synthetic route of 13623-11-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mahesh; Karpagam; Journal of Fluorescence; vol. 26; 4; (2016); p. 1457 – 1466;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67899-00-7,2-Amino-4-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

To a suspension of 6 (500mg, 3.20mmol) in tetrahydrofuran (20mL) were added pyridine (1.30mL, 16.0mmol) and acetyl chloride (0.60ml, 7.90mmol) at 0C, and the reaction mixture was stirred for 21h at room temperature. After the volatiles of the mixture were removed in vacuo, water was poured into the residue, and the suspension was stirred for 1h. The resulting precipitate was collected by filtration, washed with water and dried in vacuo to yield 7 (585mg, 91%) as a colorless powder. 1H NMR (200MHz, DMSO-d6) delta 2.15 (s, 3H), 2.52 (s, 3H), 12.35 (br s, 1H); MS (ESI): m/z 201 [M+H]+, 223 [M+Na]+, 199 [M-H]-., 67899-00-7

As the paragraph descriping shows that 67899-00-7 is playing an increasingly important role.

Reference£º
Article; Oka, Yusuke; Yabuuchi, Tetsuya; Oi, Takahiro; Kuroda, Shoichi; Fujii, Yasuyuki; Ohtake, Hidenori; Inoue, Tomoyuki; Wakahara, Shunichi; Kimura, Kayo; Fujita, Kiyoko; Endo, Mayumi; Taguchi, Kyoko; Sekiguchi, Yoshinori; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7578 – 7583;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.247037-82-7,Thiazole-2-carboximidamide hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of ethyl 3-oxobutanoate (0.4 g, 3 mmol), cyclohexanecarbaldehyde (0.34 g, 3 mmol), 1,3-thiazole-2-carboximidamide HCl salt (0.49 g, 3 mmol) and KOAc (0.59 g, 6 mmol) in CF3CH2OH (10 mL) was stirred for 24 hours at 90 C. After being cooled, it was partitioned (EtO Ac-brine). The organic was dried (Na2SO4), filtered and concentrated. The residue was chromatographed (silica, ethyl acetate/petroleum ether) to give the desired compound as a yellow solid (0.35 g, 34%). ESIMS m/z = 334.1 [M+H]+.

247037-82-7, The synthetic route of 247037-82-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; QIU, Yao-Ling; CAO, Hui; LI, Wei; PENG, Xiaowen; JIN, Meizhong; KASS, Jorden; GAO, Xuri; OR, Yat, Sun; (99 pag.)WO2017/11552; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2516-40-7,2-Bromobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: A 10 mL Schlenk tube equipped with a stir bar was sealed with a rubber septum,It was dried using a heat gun under reduced pressure (about 400 ¡ã C.)It was then filled with argon.Further, reduced pressure – argon filling was repeated twice to make the inside of the Schlenk tube completely under an argon atmosphere.0.5 mL of N, N’-dimethylpropyleneurea (hereinafter referred to as DMPU) as a solvent,0.71 mL of diethylzinc (1.02 M hexane solution: 1.5 eq),386.25 mg of nonafluorobutyl iodide (1.125 mmol, 2.25 eq) were sequentially added at room temperature using a syringe.Further, 0.5 mmol of 208.2 mg of dodecyl 2-iodobenzoate (0.5 mmol, 1 equivalent) as an electrophile,9.5 mg of copper iodide (0.05 mmol: 0.1 eq) was added,After replacing the rubber septum with a glass stopper, it was heated at 90 ¡ã C. for 16 hours.After allowing the reaction mixture to cool to room temperature, the reaction was stopped with 20 mL of 1 N hydrochloric acid,And extracted three times with diethyl ether having a total volume of 100 mL.The combined organic layer was washed with saturated brine,After drying with magnesium sulfate, the solvent was distilled off with a rotary evaporator.The crude product was purified by flash column chromatography (methylene chloride / hexane 1: 7)226.2 mg of the desired product was obtained (89percent, pale yellow oil)., 2516-40-7

2516-40-7 2-Bromobenzothiazole 612040, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; THE UNIVERSITY OF TOKYO; UCHIYAMA, MASANOBU; HIRANO, KEIICHI; (29 pag.)JP2015/86221; (2015); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

13743-09-4, 2-Methyl-5-phenylthiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 56:Compound 7: (2-methyl-5-phenylthiazol-4-yl)(5-((5-(trifluoromethyl)pyridin-2- ylamino)methyl)-6-azaspiror2.51octan-6-yl)methanoneIntermediate 9 (60 mg, 0.210mmol) ) was dissolved in dichloromethane (2ml), diisopropyl ethylamine (121 ul, 0.693mmol) and 0-(benzotriazol-1 -yl)-N,N,N’N’- tetramethyluronium hexafluorophosphate (1 12mg, 0.294mmol) were added. After 30 minutes at room temperature 2-methyl-5-phenylthiazole-4-carboxylic acid (65mg, 0.294mmol) was dissolved in dichloromethane (2ml) and dimethylformamide (1 ml) and added to the reaction. After 18 hours at room temperature the mixture was poured in aqueous NaHCO3 saturated solution and extracted with ethylacetate. The organic layers were combined, dried (Na2SO4) and concentrated under vacuum; the obtained crude product was purified by silica gel column chromatography (gradient from dichloromethane/Ethyl acetate =1/1 to Ethyl acetate), thus obtaining 15 mg of compound 7 as white solid.MS (ESI) m/z 509 [M+Na]+. 1HNMR [the product is present as a mixture of conformers. The assignment refers to the major component] (CD3OD) d ppm 8.05 (s, 1 H) 7.39-7.60 (m, 5H) 6.41 (d, 1 H) 4.65 (m, 1 H) 4.20 (m, 1 H) 3.69-3.76 (m, 1 H) 3.28-3.35 (m, 1 H) 3.10-3.15(m, 1 H) 2.43 (s, 3H) 1.82 (m, 1 H) 1.30-1.45 (m, 1 H) 0.90-1.05 (m, 2H) 0.6-0.68 (m, 1 H) 0.30-0.55 (m, 2H) 0.15-0.25 (m, 2H).

13743-09-4, 13743-09-4 2-Methyl-5-phenylthiazole-4-carboxylic acid 943535, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ROTTAPHARM S.P.A.; STASI, Luigi, Piero; ROVATI, Lucio; WO2011/6960; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

349-49-5, 4-(Trifluoromethyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 3 2-Imino-3-methyl-4-trifluoromethyl-4-thiazoline fluorosulfonate 336 mg. of 2-amino-4-trifluoromethylthiazole was dissolved in 15 mg. CH2 Cl2. The flask was placed in an ice bath and 240 mg. of CH3 SO3 F in 5 ml. CH2 Cl2 was added. The mixture was then placed in a refrigerator over the weekend. The colorless crystals were collected on a filter to give 450 mg. (80percent) of 2-imino-3-methyl-4-trifluoromethyl-4-thiazoline fluorosulfonate, m.p. 177¡ã-178¡ã C., 349-49-5

The synthetic route of 349-49-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck & Co., Inc.; US4029803; (1977); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

22900-83-0, Ethyl 2-bromo-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Fluorophenol (Sigma-Aldrich; 2 g; 17.84 mmol), ethyl 2-bromo-4-methylthiazole-5- carboxylate (Ark Pharm; 4 g; 16 mmol), and cesium carbonate (Sigma-Aldrich; 6.24 g; 19.15 mmol) were thoroughly mixed in 32 ml anhydrous dimethylsulfoxide, and the resulting slurry stirred vigorously 16 h at 45¡ãC. After cooling to 25¡ãC, the reaction mixture was poured into 200 ml water. Organics were extracted with 4×100 ml ether, and the pooled extracts were washed with 50 ml water, washed with 50 ml brine, dried over anhydrous sodium sulfate, filtered, and concentrated to 4.51 g brown solid. NMR showed the desired product, ethyl 2- (4-fluorophenoxy)-4-methylthiazole-5-carboxylate, which was used in the next step without further purification. Yield: 4.51 g (100percent).1H NMR (400 MHz, CDCb): d 7.21 (m, 2H), 7.05 (m, 2H), 4.28 (q, 2H),) 2.48 (s, 3H), 1.32 (t, 3H, 22900-83-0

22900-83-0 Ethyl 2-bromo-4-methylthiazole-5-carboxylate 2824057, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; EBRIGHT, Richard H.; EBRIGHT, Yon W.; (72 pag.)WO2019/160873; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

13838-78-3, 5-Methylthiazole-2-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 3; 2-[[N-(5-Methyl-1 ,3-thiazol-2-yl)methylene]amino]-3-(1 ,3-thiazol-4-yl)propanoic acid, te/1-butyl ester A mixture of 2-amino-3-(1 ,3-thiazol-4-yl)propanoic acid, terf-butyl ester (Intermediate 2; 2.90 g, 12.7 mmol), 5-methyl-1 ,3-thiazole-2-carboxaldehyde (1.62 g, 12.7 mmol) and magnesium sulfate (ca. 1g) in dichloromethane (70 mL) was stirred at room temperature for 18 hours. The reaction mixture was filtered, and the filtrate was evaporated to remove solvent, to give the title compound as an oil.1H NMR (CDCI3): delta 8.75 (d, 1 H), 8.11 (s, 1 H), 7.55(br, 1 H), 7.02 (d, 1 H), 4.45 (dd, 1 H), 3.56 (dd, 1 H), 3.33 (dd, 1 H), 2.50 (br s, 3H) and 1.44 (s, 9H)., 13838-78-3

The synthetic route of 13838-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/45613; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica