With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13623-11-5,2,4,5-Trimethylthiazole,as a common compound, the synthetic route is as follows.
2,4,5-trismethyl thiazole (2.5 g, 19.65 mmol), N-bromosuccinimide(10.49 g, 58.96 mmol) and benzoyl peroxide (30 mg) were dissolved in 150 ml of CCl4. Resulting mixture was stirred at 70 C for 5 h. After cooling, succinimide salt was removed by water washing and product was extracted by DCM (50 ml ¡Á 2).To this organic layer washed with brine solution and dried over Na2SO4. This product was also not stable at room temperature for long time and it was stable only at below 15 C in DCMsolvent. This crude product was also used for further synthesiswithout purification.
13623-11-5, The synthetic route of 13623-11-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Mahesh; Karpagam; Journal of Fluorescence; vol. 26; 4; (2016); p. 1457 – 1466;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica