173979-01-6, 4-(Tributylstannyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 63 (3-Chloro-5-thiazol-4-yl-phenyl)-(1 H-imidazol-2-yl)-methanoneA solution of Example 53 (50 mg, 0.15 mmol) in 1 ,4-dioxane (3 ml_) was stirred in a microwave reaction tube. 4-Tributylstannanyl-thiazole (62 mg, 0.165 mmol) followed by Pd(PPh3)4 (10 mg, 8.6 mumol) was added to the stirred mixture. The tube was sealed and the reaction was heated at 1200C for 30 mins. The mixture was then diluted with EtOAc (20 ml.) and washed with brine. The organic phase was then dried over Na2SO4, filtered and the solvent evaporated. The crude was triturated in dichloromethane and the collected precipitate was purified further by SiO2 chromatography (Hexanes/ EtOAc; 9:1 to 2:1 ) to give the title compound as a beige solid (10 mg, 23%). MS(ESI) m/z 289.9 (M+H)+. 1H NMR (400 MHz, DMSO-d6): 13.62 (1 H, s), 9.28 (1 H, d), 8.97 (1 H, t), 8.58 (1 H, t), 8.46 (1 H, d), 8.34 (1 H, t), 7.58 (1 H, s), 7.39 (1 H, s).
173979-01-6, The synthetic route of 173979-01-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; ASTEX THERAPEUTICS LIMITED; HOWARD, Steven; MORTENSON, Paul Neil; HISCOCK, Steven Douglas; WOOLFORD, Alison Jo-Anne; WOODHEAD, Andrew James; CHESSARI, Gianni; O’REILLY, Marc; CONGREVE, Miles Stuart; DAGOSTIN, Claudio; CHO, Young Shin; YANG, Fan; CHEN, Christine Hiu-Tung; BRAIN, Christopher Thomas; LAGU, Bharat; WANG, Yaping; KIM, Sunkyu; GRIALDES, John; LUZZIO, Michael Joseph; PEREZ, Lawrence Blas; WO2010/125402; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica