With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106092-09-5,(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.
Weigh 1.5g of 2-methyl-3-oxopentanoic acid, 1.9g of (S) -2,6-diamino-4,5,6,7-tetrahydrobenzothiazole and 2.3g of triethylamine In a 100 mL single-necked flask, 20 mL DMF was added and stirred well followed by 5.2 g HBTU. The reaction system was stirred at room temperature for 3h. The reaction mixture was diluted with 50 mL of water and extracted three times with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate. The resulting residue was purified by column chromatography to give 2.4 g of light yellow solid with a yield of 74.1%
106092-09-5, 106092-09-5 (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole 11521153, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; Chengdu Beite Pharmaceutical Co., Ltd.; Liu Guanfeng; Huang Haoxi; Ren Junfeng; Wu Xiancai; Chen Tonghun; Li Yingfu; Su Zhonghai; (9 pag.)CN106749092; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica