5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1 Preparation of ethyl 2-chlorothiazol-4-carboxylate 17 g (100 mmol) ethyl 2-aminothiazol-4-carboxylate (Example 30, step 1) was added to 150 ml acetonitrile, and 18.5 g (110 mmol) dihydrated cupric chloride was added, and then, with mechanical stirring, 18.5 ml (130 mmol) isoamyl nitrite was slowly added dropwise, followed by continuing the reaction for 4 hr after complete of addition. To the resulting mixture, ethyl acetate and water were added, filtered to remove insoluble solids, and the layers were separated. The aqueous phase was further extracted with ethyl acetate, the resultant organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to obtain 16 g of an oily liquid 1H NMR (CDCl3) 1.39-1.43(3H,t, J=7.0Hz); 4.40-4.44(2H,m, J=7.0Hz); 8.08(1H, s).
5398-36-7, 5398-36-7 Ethyl 2-aminothiazole-4-carboxylate 73216, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; Beijing Molecule Science and Technology Co., Ltd.; EP2039686; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica