53332-78-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53332-78-8,Thiazol-2-ylmethanamine dihydrochloride,as a common compound, the synthetic route is as follows.
General procedure: A mixture of the intermediate obtained from step 2 (1.00 g; 2.96 mmol), HATU (1.24 g; 3.25 mmol), DMF (2.50 mL) and DIPEA (0.56 mL; 3.25 mmol) is stirred at r.t. for 20 min. The amine 4-cyanobenzylamine (0.36 mL, 2.96 mmol) is added and the resulting mixture is stirred at r.t. for 2 h. A molar surplus of aq. NaHCOs solution is added with stirring and the precipitate is filtered off and dried at 50 C to yield the title compound. C20H19CI2N3O3S ESI pos.+neg. (Loop-Inj.): [M+H]+ 452 m/z (0129) HPLC (RT): 0.70 min (HPLC method A)
53332-78-8 Thiazol-2-ylmethanamine dihydrochloride 44890709, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KLEY, Joerg; KAUSCHKE, Stefan; PAUTSCH, Alexander; WIEDENMAYER, Dieter; (41 pag.)WO2018/104220; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica