With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55707-55-6,Di(2-thiazolyl)methanone,as a common compound, the synthetic route is as follows.
55707-55-6, General procedure: In a flame-dried apparatus and under argon atmosphere, a solution of cis-propenylbromide(0.425 mL, 0.005 mol) in anhydrous THF (30 mL) was added dropwise to magnesium turnings(0.005 mol) in THF (5.0 mL). After a gentle warming the Grignard formation was observed and thereaction was allowed until the magnesium was consumed. The resulting solution was withdrawn witha graduate syringe and a half amount was inserted in a dropping funnel and the other half in anotherone. Each funnel was connected with a flame-dried round-bottomed flask in which 0.00025 mol ofketone were dissolved in 5.0 mL of anhydrous THF and kept at -70 C. After about 15 min fromthe addition of the Grignard solution, the reaction was quenched with aqueous (NH4)2SO4 andextracted with diethyl ether. The organic layer was dried over anhydrous Na2SO4, and the solventwas removed after filtration. The reaction mixture was analyzed through 1H-NMR spectroscopy.The reaction products were recognized by comparison with literature data in case of reaction withbenzophenone [25] and with data obtained in experiments reported in Table 1, entries 5 and 6.
55707-55-6 Di(2-thiazolyl)methanone 13331906, athiazole compound, is more and more widely used in various fields.
Reference£º
Article; Boga, Carla; Bordoni, Silvia; Casarin, Lucia; Micheletti, Gabriele; Monari, Magda; Molecules; vol. 23; 1; (2018);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica