With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.405939-39-1,tert-Butyl (5-bromothiazol-2-yl)carbamate,as a common compound, the synthetic route is as follows.
Example 15, Step F[00158] To LDA (177.21 mmol) in THF (100 mL) was added compound 15_2 (15 g, 53.7 mmol) in THF dropwise at 0C under N2 and the mixture stirred at 0C for 15 mins. Diethyl pyrocarbonate (28.73 g, 177.21 mmol) was then added dropwise at 0C and the reaction mixture stirred at room temperature overnight. The mixture was diluted with EtOAc and washed with water, brine, dried over MgS04 and concentrated in vacuo. The residue was purified by silica column chromatography (PE: EtOAc=10:1) to afford product 15_3 (6 g, 32% yield).[00159] This compound was characterized by proton NMR (1HNMR) in accordance with the procedures described herein. Proton NMR yielded the following results: 1H NMR (CDCI3, 400 MHz): delta 9.409 (brs, 1 H), 4.367 (q, 2H, J=7.2 Hz), 1.577 (s, 9H), 1.380 (t, 3H, J=7.2 Hz).
405939-39-1, As the paragraph descriping shows that 405939-39-1 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; ADDEX PHARMA S.A.; LIVERTON, Nigel, J.; BOLEA, Christelle; CELANIRE, Sylvain; YUNFU, Luo; WO2012/8999; (2012); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica