With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.100367-77-9,Ethyl 2-bromothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
Step 3 : (2-bromothiazol-4-yl)methanolA solution of ethyl 2-bromothiazole-4-carboxylate (7.821 g, 33.13 mmol) in THF (100 mL) was cooled in an ice-bath and treated portionwise with lithium borohydride (1.083 g, 49.70 mmol). After 1 hour MeOH (1.614 g, 2.040 mL, 50.36 mmol) was added over a period of half an hour. The reaction was allowed to stir for 3 hours and then the solvent was concentrated in vacuo and the resultant residue was dissolved in EtOAc, washed with HCl (2x), saturated sodium bicarbonate, followed by brine, dried (Na2SO4), concentrated and purified by column chromatography (EtOAc/Petroleum ether 1: 1) to give the required product as a colorless oil (4.3Og, 67percent Yield). 1H NMR (CDCl3, 400 MHz) delta 2.51 (IH, m), 4.75 (2H, m), 7.19 (IH, s); MS (ES+) 195.96, 100367-77-9
100367-77-9 Ethyl 2-bromothiazole-4-carboxylate 353965, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; JIMENEZ, Juan-Miguel; COLLIER, Philip, N.; WO2010/129668; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica