Day: October 27, 2020

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 12 3-[(5-nitrothiazol-2-yl)mercapto]-5-phenyl-1,2,4-triazole (SU4390) (Compound 7) The key starting material 2-bromo-5-nitrothiazole was prepared by treating 2-amino-5-nitrothiazole (Aldrich) with sodium nitrite and hydrogen bromide (Fr. Demande 2,015,434, 1970)., 121-66-4

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Patent; Sugen, Inc.; US5883110; (1999); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7210-76-6,Ethyl 2-amino-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

7210-76-6, A mixture of 2-amino-4-methyl-thiazole-5-carboxylic acid ethyl ester (1.0 g, 5.4 mmol) inN,N-dimethylformamide at [25 oC] was treated with triethylamine (1.89 mL, 13.5 mmol) and triphenylmethylchloride (1.66 g, 5.94 mmol). The reaction was stirred at [2 oC] for 2 days. At this time, the reaction was concentrated in vauco. The residue was dissolved in dichloromethane (100 mL) and was washed with a IN aqueous hydrochloric acid solution (1 x 20 mL), a saturated aqueous sodium bicarbonate solution [(1] x 20 mL), and a saturated aqueous sodium chloride solution [(1] x 20 mL). The organics were dried over magnesium sulfate, filtered, and concentrated in vacuo to afford 4-methyl-2- (trityl-amino)-thiazole-5-carboxylic acid ethyl ester (2.3 g, quant.). The product was used without further purification: LR-MS for [C26H24N202S] [(M-H) +] at [RN/Z = 427.]

7210-76-6 Ethyl 2-amino-4-methylthiazole-5-carboxylate 343747, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2003/106459; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

7238-61-1,7238-61-1, 2-Bromo-4-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A dioxane (10.00 mL) mixture of a compound WX022-1 (206.90 mg, 1.50 mmol), a compound WX022-2 (222.56mg, 1.25 mmol), [1,1?-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) (94.16 mg, 0.125 mmol) and sodium carbonate(264.98 mg, 2.50 mmol) was reacted at 85 C for 3 hours under the protection of nitrogen. After the reaction wascompleted, the mixture was cooled down and 1M hydrochloric acid was added to adjust the pH to 6. The mixture wasdiluted with 10 mL of water, and extracted with 20mL of ethyl acetate twice, and the water phase was adjusted withNaHCO3 (aq) to a pH of 8. Then the mixture was extracted with 20mL of ethyl acetate twice, dried with anhydrous sodiumsulfate and spin-dried to obtain the compound WX022-3. 1H NMR (400MHz, CHLOROFORM-d) delta = 7.81 (br d, J=7.8Hz, 2H), 6.90 (br d, J=8.3 Hz, 1H), 6.94-6.87 (m, 1H), 6.80 (s, 1H), 2.49 (s, 3H).

7238-61-1 2-Bromo-4-methylthiazole 551541, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Shandong Danhong Pharmaceutical Co., Ltd.; LUO, Zhi; LI, Xiaolin; YANG, Yaxun; YANG, Lele; LI, Peng; HE, Haiying; LI, Jian; CHEN, Shuhui; (155 pag.)EP3626699; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

405939-39-1,405939-39-1, tert-Butyl (5-bromothiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of diisopropylamine (64 ml, 446 mmol) in 200 mL of tetrahydrofuran was added to a dry three-neck bottle, which was protected under nitrogen, and cooled to 0 C, and then n-butyllithium (2.5M, 173ml, 431.7mmol) was added. The reaction was conducted for 1 hour after addition was completed. A solution of tert-butyl 5-bromothiazol-2-ylcarbamate in 400 mL of tetrahydrofuran was added dropwise at 0 C, and the reaction was conducted for 2 hours after addition was completed. TLC showed the reaction was completed. At 0 C, the reaction was quenched by slow addition of ice water (5 mL), stirred for 30 min, then saturated ammonium chloride (500mL) aqueous solution was added, and separated. The aqueous layer was extracted with dichloromethane (2 ¡Á 300 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was recrystallized with petroleum ether : ethyl acetate = 30:1 to give 31g of tert-butyl 4-bromothiazol-2-ylcarbamate as a white solid, yield 77.5%, MS(ESI): m/z 278.98 (M + H)+.

As the paragraph descriping shows that 405939-39-1 is playing an increasingly important role.

Reference£º
Patent; Genfleet Therapeutics (Shanghai) Inc.; ZHOU, Gang; (44 pag.)EP3613737; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.94284-66-9,1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone (1 mol) in methanol (4.0-4.1 l), was added dropwise to a cooled solution of corresponding aromatic aldehydes (1 mol) in 10% NaOH (600-650 ml). The solution was maintained at 0 C for 1.5 h and then was allowed to stir at room temperature. After some time (5-12 h) solid started separating out. The solid was filtered under vacuum and recrystallized from dioxane or ethanol to give the title chalcones. The yield range after recrystallization of chalcones was 32-84%., 94284-66-9

As the paragraph descriping shows that 94284-66-9 is playing an increasingly important role.

Reference£º
Article; Liaras; Geronikaki; Glamo?lija; ?iri?; Sokovi?; Bioorganic and Medicinal Chemistry; vol. 19; 10; (2011); p. 3135 – 3140;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-80-5,Thiazole-4-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A solution of substituted o-phenyldiamine (1.0 equiv), thiazole-4-aldehyde or pyridine-2-aldehyde (1.0 equiv) with sodium pyrosulfite in DMF was stirred at 120¡ã C overnight. On completion of the reaction monitored by TLC, the solvent was evaporated and the residue was purified by silica gel chromatography by DCM/MeOH system to afford the final product. If necessary, the crudeproduct could be recrystallized in DCM or dichloroethane to afford pure sample., 3364-80-5

The synthetic route of 3364-80-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Chao; Zhong, Bo; Yang, Simin; Pan, Liangkun; Yu, Siwang; Li, Zhongjun; Li, Shuchun; Su, Bin; Meng, Xiangbao; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3774 – 3780;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

78364-55-3, 6-Fluoro-2-hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

78364-55-3, General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

20358-03-6, 2-Amino-5-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2.0 g of 2-amino-5-bromobenzothiazole was dissolved in 20.0 mL of pyridine, 688 uL of acetyl chloride was added thereto, and the resulting solution was stirred overnight at room temperature. The reaction mixture thus obtained was concentrated, and then ethyl acetate and 1N aqueous solution of hydrogen chloride were added thereto, and the resulting solution was stirred for about 30 minutes. The solid thus obtained was filtered under reduced pressure while it was washed with ethyl acetate, to give 1.18 g of the title compound as a white solid (yield: 49.8 %). 1H-NMR (CDCl3, 400 MHz) d 9.7l(bs, 1H0, 7.9l(s, 1H), 7.68(d, 1H), 7.43(d, 1H), 2.32(s, 3H), 20358-03-6

As the paragraph descriping shows that 20358-03-6 is playing an increasingly important role.

Reference£º
Patent; YUHAN CORPORATION; HAN, Tae Dong; TAK, Hee Jae; KIM, Eun Kyung; CHOI, Su Bin; KIM, Dong Hoon; PARK, Sol; JUNG, Eun Hye; CHOI, Hyun Ho; KIM, Tae Wang; JU, Mi Kyeong; HA, Na Ry; (305 pag.)WO2019/180644; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29182-42-1,Ethyl 2-(benzo[d]thiazol-2-yl)acetate,as a common compound, the synthetic route is as follows.,29182-42-1

General procedure: To an oven-dried and argon-filled Schlenk tube was added 2-substituted benzo[d]thiazole component 1 (0.5 mmol), 2-bromoenal 2 (0.75 mmol, 1.5 equiv), triazolium salt C (0.05 mmol,10 mol%), and DIPEA (0.6 mmol, 1.2 equiv) in toluene (5 mL).The mixture was stirred at r.t. and monitored by TLC until completion of the reaction. The residue was purified by flash chromatography on silica gel [n-pentane-Et2O (10:1) or n-pentaneCH2Cl2 (1:1 to 1:2)] to afford the products 3a-k as orange oryellow solids.

The synthetic route of 29182-42-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ni, Qijian; Xiong, Jiawen; Song, Xiaoxiao; Raabe, Gerhard; Enders, Dieter; Synlett; vol. 26; 11; (2015); p. 1465 – 1469;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5198-88-9,2-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

3-[(2-bromo-thiazole-4-carbonyl)-annino]-3-o-tolyl-propionic acid methyl ester100mg (0,48mnnol) of 2-bromo-l ,3-thiazole-4-carboxylic acid are dissolved in 10 ml of DMF, N-ethylmorpholine (122 mg, 2,2Eq) and TOTU (174mg, 1 .1 Eq) are added and the mixture is stirred at RT for 5 minutes. Then 93mg (1 Eq) of methyl 3-amino-3-(2- methylphenyl)propanoate are added and the mixture is stirred overnight. The solvent is removed in vacuo and the residue subjected to preparative HPLC delivering 3-[(2- bromo-thiazole-4-carbonyl)-amino]-3-o-tolyl-propionic acid methyl ester yields in yields below 80%, 5198-88-9

As the paragraph descriping shows that 5198-88-9 is playing an increasingly important role.

Reference£º
Patent; SANOFI; RUF, Sven; PERNERSTORFER, Josef; SADOWSKI, Thorsten; HORSTICK, Georg; SCHREUDER, Herman; BUNING, Christian; WIRTH, Klaus; WO2013/14205; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica