Analyzing the synthesis route of 3034-57-9

3034-57-9, 3034-57-9 2-Amino-5-bromo-4-methylthiazole 12954373, athiazole compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-57-9,2-Amino-5-bromo-4-methylthiazole,as a common compound, the synthetic route is as follows.

2-Amino-5-bromo-4-trifluoromethylthiazole (0.8 g) was dissolved in 3 ml_ of 1 :1 mixture of THF and pyridine. 2,6-difluorobenzoylchloride (0.6 g) was added at room temperature with stirring. The mixture was stirred for 3 hours at room temperature. The mixture was poured into ice water and acidified with aqueous hydrochloric acid then extracted with chloroform. The organic layer was dried over Na2SO4 and the solvent was removed under reduced pressure. Flash chromatography on silica gel gave the title compound as a white solid. Yield 83percent.

3034-57-9, 3034-57-9 2-Amino-5-bromo-4-methylthiazole 12954373, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; SYNTA PHARMACEUTICALS CORP.; WO2007/87427; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica