Brief introduction of 3364-78-1

3364-78-1 2-(Chloromethyl)thiazole 14090864, athiazole compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-78-1,2-(Chloromethyl)thiazole,as a common compound, the synthetic route is as follows.

Step-(iii): A stirred solution of O (0.97 g, 6.46 mmol), G (1 g, 3.23 mmol) and potassium carbonate (1.33 g, 9.69 mmol) in dry DMF (10 ml) was degassed with nitrogen for 10 minutes. After 10 minutes Pd(dppf)2Cl2 (260 mg, 0.32 mmol) was added, again degassed with nitrogen for 10 minutes and the reaction mixture was stirred at 1 10C for 14 h. The progress of the reaction was monitored by TLC. After 14 h of stirring, the mixture was cooled to 20- 35C, diluted with water (100 ml) and extracted with ethyl acetate (2 x 100- ml). The combined organic layers were washed with brine (100 ml), followed by drying over anhydrous Na2SC>4 and filtering. The filtrate was rotary evaporated to get residue which was purified by column chromatography using a mixture of 30% ethyl acetate/hexane as an eluent to get the desired compound as a palebrown liquid (400 mg, 44%). NMR (400 MHz, DMSO-d6) delta 7.70 (d, J = 3.4 Hz, 1H), 7.60 (d, J = 3.5 Hz, 1H), 5.60 (s, 1H), 3.82 (s, 2H), 3.71 (s, 2H), 3.38 (t, J = 5.9 Hz, 2H), 2.06-1.96 (m, 2H), 1.40 (s, 9H)., 3364-78-1

3364-78-1 2-(Chloromethyl)thiazole 14090864, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana; WO2013/80222; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica