With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76874-79-8,2-Amino-4-chlorothiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.
EXAMPLE 4; 16.3 parts of 2-amino-4-chloro-5-formylthiazole are dissolved in 100 parts of sulphuric acid 93% and admixed with 32 parts of nitrosylsulphuric acid 40% at 0 to 5C in the course of 30 minutes. This is followed by 3 hours of stirring in an icebath, and the diazonium salt solution is poured continuously into a mixture of 41.0 parts of phenylcarbonylmethyl 3- [N-allyl-N- (5′-acetylamino-2′-methoxy-phenylamino)]- propionate, 100 parts of glacial acetic acid, 2 parts of sulphamic acid and 300 parts of ice/water. The precipitated dye is filtered off, washed acid free with water and dried at 60C under reduced pressure. The dye obtained, which has Amax = 625 (DMF), conforms to the formula and dyes polyester materials in greenish navy shades and is useful as individual dye or in navy and black mixtures for the eForon RD rapid-dyeing process, with very good fastnesses, 76874-79-8
As the paragraph descriping shows that 76874-79-8 is playing an increasingly important role.
Reference£º
Patent; CLARIANT INTERNATIONAL LTD; WO2005/56690; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica