78441-62-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78441-62-0,2-(((2-((Dimethylamino)methyl)thiazol-4-yl)methyl)thio)ethanamine,as a common compound, the synthetic route is as follows.
EXAMPLE 3 According to the general procedure of Example 2, a solution of 1.65 (6.8 mmol) of 95percent pure 4-[[(2-aminoethyl)thio]methyl]-N,N-dimethyl-2-thiazolemethanamine and 1.8 g (7.0 mmol) of 1,1-diphenoxy-2-nitroethene dissolved in 25 ml of methylene chloride was stirred at room temperature for about two hours to provide N-[2-[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-2-nitro-1-phenoxy-1-etheneamine in situ. This compound was reacted with gaseous monomethylamine to provide 0.8 g of nizatidine. Yield 35.5percent.
As the paragraph descriping shows that 78441-62-0 is playing an increasingly important role.
Reference£º
Patent; Eli Lilly and Company; US4777260; (1988); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica