With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-32-3,Thiazole-5-carboxyaldehyde,as a common compound, the synthetic route is as follows.
General procedure: To a mixture of imidazole (0.1 mol), (furan-2-ylmethylidene)hydrazine (0.1 mol), and 4-subsituted benzaldehyde (0.1 mol) in 30 cm3 of EtOH was added Cu(Phen)Cl2(10 mol %) at room temperature. The reaction mixture was refluxed for 5 h. The reaction was checked by TLC, and then the solvent was removed under reduced pressure. The final product was purified by flash column chromatography on silica gel using n-hexane/EtOAc., 1003-32-3
The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Alaklab, Abdullah; Surendra Kumar, Radhakrishnan; Ahamed, Anis; Arif, Ibrahim A.; Manilal, Aseer; Idhayadhulla, Akbar; Monatshefte fur Chemie; vol. 148; 2; (2017); p. 275 – 290;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica