693-95-8, 4-Methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,693-95-8
Step 1 : 2-(aminomethyl)-5-(4-methyl-l,3-thiazol-5-yl)phenol (BI)[0459] To a stirred solution of 2-hydroxy-4-(4-methyl- l,3-thiazol-5-yl)benzonitrile (BH,15.6 g, 72.14 mmol) in tetrahydrofuran (400 mL) under an atmosphere of nitrogen was added LiAlH4(11 g, 289.86 mmol) in several portions at 10 ¡ãC. The resulting mixture was then heated to reflux for 3 h, LC-MS indicated formation of the desired product. The reaction was then cooled to 0 ¡ãC, quenched by the water (10 mL, added slowly and drop wise), 15percent NaOH (aq.) (30 mL) and water (10 mL). The solids precipitated were removed by filtration, the solution phase was concentrated under reduced pressure followed by high vacuum pump to give BI(yield: 65percent). LC-MS (ES+): m/z 220.85 [MH+], tR= 1.02 min (2.6 minute run).
The synthetic route of 693-95-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ARVINAS, INC.; JIN, Meizhong; CREW, Andrew, P.; DONG, Hanqing; WANG, Jing; SIU, Kam; FERRARO, Caterina; CHEN, Xin; QIAN, Yimin; (351 pag.)WO2016/118666; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica