1235406-42-4, tert-Butyl thiazol-4-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of tert- butyl thiazol-4-ylcarbamate (1.09 g, 5.46 mmol) in anhydrous tetrahydrofuran (40 ml_) was added a 1 M solution of lithium (1005) bis(trimethylsilyl)amide in tetrahydrofuran (5.5 ml_, 5.5 mmol) at -78 C. The reaction mixture was stirred at -78 C for 20 minutes, allowed to warm to ambient temperature and stirred for 1 hour. The reaction mixture was cooled to -78 C, and a solution of 5- fluoro-4-(trifluoromethyl)pyridine-2-sulfonyl chloride (1.20 g, 4.55 mmol) in anhydrous tetrahydrofuran (5 ml_) was then added dropwise. The reaction mixture was stirred at – 78 C for 30 minutes, allowed to warm to ambient temperature, and stirred for 16 hours. After addition of saturated aqueous ammonium chloride (50 ml_), the mixture was extracted with ethyl acetate (3 c 50 ml_). The combined organic phases were washed with brine (50 ml_), dried over anhydrous sodium sulfate, and filtered. (1006) Concentration of the filtrate in vacuo and purification of the residue by column chromatography, eluting with a gradient of 5% to 50% of ethyl acetate in heptane, afforded the title compound as a light yellow solid (0.90 g, 46% yield): 1H NMR (300 MHz, CDCIs) 8.81 (d, J = 2.3 Hz, 2H), 8.53 (d, J = 5.3 Hz, 1 H), 7.64 (d, J = 2.3 Hz, 1 H), 1.29 (s, 9H); MS (ES+) m/z 328.0 (M – 99).
1235406-42-4, The synthetic route of 1235406-42-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; XENON PHARMACEUTICALS INC.; FOCKEN, Thilo; ANDREZ, Jean-Christophe; BURFORD, Kristen Nicole; DEHNHARDT, Christoph Martin; GRIMWOOD, Michael Edward; JIA, Qi; LOFSTRAND, Verner Alexander; WILSON, Michael Scott; ZENOVA, Alla Yurevna; WESOLOWSKI, Steven Sigmund; SUN, Shaoyi; (205 pag.)WO2020/47323; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica