Month: October 2020

1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5A 2-Amino-6-sulphanyl-4-(1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile 1.14 g (9.539 mmol) of 5-thiazolecarboxaldehyde and 1.91 g (19.077 mmol) of cyanothioacetamide are initially charged in 20 ml of ethanol, 2.097 ml (19.077 mmol) of 4-methylmorpholine are added and the mixture is heated under reflux for 4 hours. The mixture is then stirred at room temperature for 20 hours. The reaction mixture is concentrated and the residue is purified on silica gel (mobile phase: methylene chloride/methanol 100:0?10:1). The product-containing fractions are concentrated and the residue is triturated with acetonitrile. The solid is filtered off and dried under high vacuum. This gives 920 mg (37% of theory) of the target compound. 1H-NMR (400 MHz, DMSO-d6): delta=9.31 (s, 1H), 8.16 (s, 1H), 7.50-6.99 (s br, 2H). LC-MS (Method 2): Rt=1.29 min; MS (ESIpos): m/z=260 [M+H]+., 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER SCHERING AKTIENGESELLSCHAFT; US2011/136871; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,78364-55-3

General procedure: Equimolar amounts of appropriate 2-hydrazinobenzothiazole1a-b, alpha-cyanoacetophenone 2a-c, and PTSA were mixed thoroughly in pestle mortar and heated on water bath for 4-5 min and then equimolar amount of appropriate trifluoromethyl beta-diketones 3a-d was added to it and mixed thoroughly. The reaction mixture was again heated 80-90 ¡ã C for 15 min on water bath. The solid was obtained by addition of aq. ethanol, filtered and crystallized from the mixture of ethanol and chloroform to give pure 4.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Aggarwal, Ranjana; Kumar, Virender; Bansal, Anshul; Sanz, Dionisia; Claramunt, Rosa M.; Journal of Fluorine Chemistry; vol. 140; (2012); p. 31 – 37;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7210-76-6,Ethyl 2-amino-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.,7210-76-6

General procedure: A solution of 2-amino-5-substituted-4-methylthiazole (1) (0.01 mol) (1a:1.2 g, 1b:1.3 g, 1c:1.6 g, 1d:1.9 g, 1e:1.9 g)[29, 30] and triethylamine (0.01 mol) (1.5 mL) was prepared by stirring in THF (50 mL) at room temperature. After cooling the mixture in an ice bath, chloroacetyl chloride (0.01mol) (0.8 mL) was added drop wise with constant stirring. Before evaporation of the solvent under reduced pressure,the reaction mixture was further stirred for 1 hour at room temperature. The precipitate formed was crystallised from ethanol [31, 12].

As the paragraph descriping shows that 7210-76-6 is playing an increasingly important role.

Reference£º
Article; Gundogdu-Karaburun, Nalan; Letters in drug design and discovery; vol. 11; 6; (2014); p. 814 – 823;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.464192-28-7,2-Bromo-5-formylthiazole,as a common compound, the synthetic route is as follows.,464192-28-7

Intermediate 103 (16.34 g, 0.086 mol) was dissolved in methanol (300 mL) and cooled to 10C. Sodium borohydride (1.63 g, 0.043 mol) was added portionwise over 15 min. The cooling bath was removed and the reaction allowed to warm to room temperature and stirred for 3 hours. The solvent was evaporated. Water (100 mL) was added followed by 1N HCI (200 mL). Ethyl acetate (450 mL) was added and the phases were separated. The organic layer was washed with brine (450 mL), dried (MgS04) and concentrated to give a brown liquid. The crude product was purified by chromatography on silica, using cyclohexane-ethyl acetate (80: 20 v/v) as eluent to give the title compound. ‘H NMR (CDCI3) : 8 7.4 (1H, s), 4.82 (2H, d), 2.96 (1H, t)

The synthetic route of 464192-28-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/37818; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

494769-44-7, tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The intermediate (3) (0.5 g, 0.00217 mol), EDCl (0.622 g, 0.00325 mol), DMAP (0.345 g, 0.0028 mol) were stirred in dichloromethane (6 mL) at 0 C, and the substituted acid (0.00217 mol) were dissolved in (4 mL) of dichloromethane and charged to the reaction mixture and stirred at room temperature for 8 h. The reaction completion was monitored by TLC. Reaction was completed. The reaction mixture was diluted with (10 mL) of dichloromethane, and was washed with 10% NaHCO3 (10 mL). Separated the organic layer and was washed with saturated brine solution (10 mL). The organic layer was dried over sodium sulfate and concentrated the organic layer under reduced pressure to afford compounds 4a-t. The spectral data of compounds 4(a-t) are given below.

494769-44-7, The synthetic route of 494769-44-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Karuvalam, Ranjith P.; Haridas, Karickal R.; Nayak, Susanta K.; Guru Row, Tayur N.; Rajeesh; Rishikesan; Kumari, N. Suchetha; European Journal of Medicinal Chemistry; vol. 49; (2012); p. 172 – 182;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1603-91-4, 4-Methylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 45Synthesis of (4-methyl-thiazol-2-yl)-carbamic acid tert-butyl ester (VIl-I) To a round bottom flask containing 40 mL CH2Cl2 was added I (695 mg, 6.09 mmol), 4-DMAP (52.3 mg, 0.43 mmol), and BoC2O (1.374 g, 6.29 mmol). The reaction mixture was stirred overnight at room temperature. Concentration of the solution in vacuo was followed by purification by column chromatography (silica gel, hexanes:EtOAc, 10: 1), affording the product as white crystals (54%).

1603-91-4, The synthetic route of 1603-91-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NORTHWESTERN UNIVERSITY; SILVERMAN, Richard, B.; JI, Haitao; LAWTON, Graham, R.; WO2008/42353; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38585-74-9,Thiazol-5-ylmethanol,as a common compound, the synthetic route is as follows.

L. ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate. A solution of 3.11 g (27 mmol) of 5-(hydroxymethyl)thiazole and excess N-methyl morpholine in 100 ml of methylene chloride was cooled to 0 C. and treated with 8.2 g (41 mmol) of 4-nitrophenyl chloroformate. After being stirred for 1 h, the reaction mixture was diluted with CHCl3, washed successively with 1N HCl, saturated aqueous NaHCO3, and saturated brine, dried over NaSO4, and concentrated in vacuo. The residue was purified by silica gel chromatography (SiO2, 1-2% MeOH/CHCl3, Rf=0.5 in 4% MeOH/CHCl3) to yield 5.9 g (78%) of the desired compound as a yellow solid. NMR (CDCl3) delta5.53 (s, 2H), 7.39 (dt, J=9, 3 Hz, 2H), 8.01 (s, 1H), 8.29 (dt, J=9, 3 Hz, 2H), 8.90 (s, 1H). Mass spectrum: (M+H)+ =281.

38585-74-9, As the paragraph descriping shows that 38585-74-9 is playing an increasingly important role.

Reference£º
Patent; Abbott Laboratories; US5484801; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

Step 1: ethyl 2-(2-((3-(trifluoromethyl)benzoyl)imino)-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-yl)acetate To a solution of 4,5,6,7-tetrahydrobenzo[d]thiazol-2-amine (200 mg, 1.297 mmol) in tetrahydrofuran (4.3 mL) were added 3-(trifluoromethyl)benzoyl chloride (324 mg, 1.56 mmol) and potassium carbonate (359 mg, 2.59 mmol). The reaction mixture was stirred at 80 C. for 5 hours and then concentrated under reduced pressure. To the resulting intermediate (0.43 mmol) were added N,N-dimethylformamide (1.5 mL) and ethyl bromoacetate (93 mg, 0.559 mmol). The reaction mixture was stirred at 80 C. for 3 hours and then cooled to room temperature. The reaction mixture was quenched with water and then extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, filtered, and then evaporated. The residue was purified with silica gel column chromatography (n-hexaneethyl acetate=41) to give 103 mg of the titled compound as a white solid (Yield: 58%). 1H NMR (CDCl3, 400 MHz) delta 12.40 (brs, 1H), 8.54 (s, 1H), 8.43 (d, 1H), 7.71 (d, 1H), 7.54 (dd, 1H), 4.90 (s, 2H), 4.24-4.30 (m, 2H), 2.59 (brs, 2H), 2.50 (brs, 2H), 1.87-1.92 (m, 4H), 1.30 (t, 3H).

2933-29-1, The synthetic route of 2933-29-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YUHAN CORPORATION; Hur, Youn; Kim, Dong-Hyun; Kim, Eun-Kyung; Park, Jin-Hwi; Joo, Jae-Eun; Kang, Ho-Woong; Oh, Se-Woong; Kim, Dong-Kyun; Ahn, Kyoung-Kyu; US2015/11528; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-78-1,2-(Chloromethyl)thiazole,as a common compound, the synthetic route is as follows.

(5- (4-Bromophenoxy) pyridin-2-yl) carbamic acid tert-butyl ester (1.460 g, 4 mmol) was dissolved in 12 mL DMFStir at room temperature, add sodium hydride (0.24g, 10mmol),After the addition was complete, the reaction was continued for 30 minutes.Then, chloromethylthiazole (1.344 g, 8 mmol) in DMF solvent (5 mL) was slowly added dropwise, and the temperature was raised to 50 C for reaction overnight.Then, 15 mL of ice water was added to the reaction, and the mixture was extracted with ethyl acetate.Combined organic phasesThe organic phase was washed with saturated brine,Dried over magnesium sulfate,Concentrated to give an oil.The oil obtained above was dissolved in 15 mL of dichloromethane.Trifluoroacetic acid (0.912g, 8mmol) was slowly added dropwise at room temperature.After the dropwise addition was completed, the mixture was stirred at 40 C and reacted overnight;The reaction was then concentrated and an aqueous potassium carbonate solution was added,Adjust the pH to 8, extract with ethyl acetate, and wash the organic phase with water.Dried, concentrated,Column chromatography [petroleum ether / ethyl acetate (v / v) = 6/4],The target compound was obtained (0.852 g, yield: 54%)., 3364-78-1

As the paragraph descriping shows that 3364-78-1 is playing an increasingly important role.

Reference£º
Patent; Dongguan Dongyangguang Pesticide Research And Development Co., Ltd.; Li Yitao; Lin Jian; Xu Junxing; Xiao Yu; Yao Wenqiang; Liu Xinshuo; (44 pag.)CN110452238; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-42-5,4-Methylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.,1477-42-5

Step 1: 4-methyl-3H-benzothiazol-2-one 5.00 g (30.5 mmol) 2-amino-4-methylbenzothiazole in 15.0 mL formic acid, 6.10 mL glacial acetic acid and 112 mL conc. hydrochloric acid were cooled to -5 C. with stirring and slowly combined with a solution of 2.10 g (30.5 mmol) sodium nitrite in 5.0 mL water. The reaction mixture was stirred for 20 min at this temperature, then heated to RT and then refluxed overnight. The cooled mixture was then mixed with water and extracted several times with EtOAc. The combined organic phases were washed with saturated sodium chloride solution, dried on sodium sulphate, filtered and the filtrate was evaporated down. Yield: 3.70 g (74% of theoretical) ESI-MS: m/z=164 (M-H)-

The synthetic route of 1477-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/59954; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica