Month: October 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.73150-67-1,2-(2-Aminothiazol-4-yl)-2-oxoacetic acid,as a common compound, the synthetic route is as follows.

This compound was then treated at 20C with a solution of 2-amino-4-thiazoleglyoxylic acid (2.61 g, 15.2 mmole) in dimethylformamide (50 ml), followed by 5 ml of water. The reaction was stirred at 20C for 20 hours, and was then chilled and diluted with 250 ml of water. Stirring of the resulting gum gave a granular solid which was filtered, washed with water, and then azeotroped with acetonitrile to dryness. The dry solid was slurried with 100 ml of acetonitrile, filtered, and finally washed sequentially with acetonitrile, ethyl ether, and hexane. Drying in air gave 1.97 g of the title compound., 73150-67-1

As the paragraph descriping shows that 73150-67-1 is playing an increasingly important role.

Reference£º
Patent; E.R. Squibb & Sons, Inc.; EP229012; (1991); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50850-93-6,Ethyl 2-aminobenzo[d]thiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

Commercially available ester 1 (1.0g, 4.5mmol) was dissolved in anhydrous THF and the RB flask was cooled to 0C. Then LiAlH4 was added slowly and the flask was stirred at 0C for additional 10min. The flask was then stirred at room temperature for 24h. The reaction was then cooled, quenched with methanol, NH4Cl Rochelle’s salt and diluted with ethyl acetate (10ml). The organic layer was separated and the aqueous layer was extracted with additional ethyl acetate (3¡Á10ml). The organic layers were combined, dried over Na2SO4 and concentrated under vacuo on a rotary evaporator to obtain a yellow solid. The crude product was purified via gradient silica gel column chromatography using a mixture of CH2Cl2 and methanol (100:1 to 5:1) to obtain the desired alcohol as yellow solid 2 (420mg, 52%). (0009) 1H NMR (500MHz, CDCl3): delta 7.57 (d, J=0.9Hz, 1H), 7.35-7.46 (m, 1H), 7.25 (dd, J=8.2, 1.8Hz, 1H), 6.45 (br s, 1H), 4.53 (s, 2H), 4.0 (br s, 1H). (0010) 13C NMR (125MHz, CDCl3): delta 167.6, 150.5, 134.9, 130.6, 125.1, 119.4, 117.7, 64.2,., 50850-93-6

The synthetic route of 50850-93-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Dutta, Aloke K.; Santra, Soumava; Harutyunyan; Das, Banibrata; Lisieski, Michael J.; Xu, Liping; Antonio, Tamara; Reith, Maarten E.A.; Perrine, Shane A.; European Journal of Pharmacology; vol. 862; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14542-12-2,Thiazol-2-ylmethanol,as a common compound, the synthetic route is as follows.

2-azidomethyl thiazole Diphenylphosphoryl azide (3.25 mL, 0.015 mol) and 1,8-diazabicyclo[5.4.0] undec-7-ene (2.25 mL, 0.025 mol) were added to a solution of thiazol-2-yl-methanol (1.44 g, 0.013 mol) in toluene (20 mL) at 0 C. After 1 hour, the reaction was warmed to room temperature and stirred overnight. The mixture was diluted with toluene (20 mL) and washed with H2 O (3*) brine (1*), dried (Na2 SO4), filtered and concentrated in vacuo. The residue was purified by flash chromatography (30% ethyl acetate/hexanes) to afford the azide as a tan oil (1.1 g, 63%). IR: 2098 cm-1. 1 H NMR (250 MHz, CDCl3) delta7.8 (d, 1H, J=2.0 Hz); 7.4 (d, 1H, J=2.0 Hz); 4.7 (s, 2H).

14542-12-2, As the paragraph descriping shows that 14542-12-2 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US5698526; (1997); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

65872-41-5, 2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1: Preparation OF 2A : (7R)-7-[(Z)-2-(2-Amino-5-chlorothiazol-4-yl)-2- (METHOXVIMINO) ACETAMIDO]-3- [ (4- (AMINOMETHYI)-1-PYDDINIO) METHYL]-3- CEPHEM-4-CARBOXYLATE Bis-trifluoroacetic Acid Salt (see Fig. 2) A. Preparation of 2-AMINO-5-CHLORO-A- .-4-THIAZOLEACETIC Acid (6) To 500mL OF DMF WERE ADDED 50.0 g (250MUNOL) OF 2-AMINO-A-(METHOXYIMINO)-4- THIAZOLEACETIC acid and 35g (260 mmol) OF N-CHLOROSUCCINIMIDE. The mixture was stirred at room temperature OVERNIGHT, after which time mass spectral analysis showed no more starting material to be present. The light brown solution was used without further purification., 65872-41-5

65872-41-5 2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetic acid 5486924, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; THERAVANCE, INC.; WO2005/5436; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-57-9, 2-Amino-5-bromo-4-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

i) 4-Methyl-5-methylsulfanyl-thiazol-2-ylamine 5-Bromo-4-methyl-thiazol-2-ylamine (1.35 g, 7 mmol,) was dissolved in methanol abs. (13.5mL) and sodium methanethiolate (0.6g, 7.7 mmol) 1.1 equiv.) was added portionwise at rt. After stirring overnight, the dark colored mixture was concentrated under reduced pressure and purified over a 50 g silica cartridge (NH2-modified) with ethyl acetate as eluent. The desired fractions were evaporated to give the title compound as a light yellow solid: 180 mg, MS (ISP): m/e 161.1 (M+H)+, 3034-57-9

3034-57-9 2-Amino-5-bromo-4-methylthiazole 12954373, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Hebeisen, Paul; Kitas, Eric A.; Minder, Rudolf E.; Mohr, Peter; Wessel, Hans Peter; US2009/143448; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

53266-94-7, Ethyl 2-(2-aminothiazol-4-yl)acetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53266-94-7, EXAMPLE 65; Step A; A neat mixture of 54 g (0.29 mole) ethyl (2-aminothiazol-4-yl)acetate and 50 g (0.276 mole) benzophenone imine was stirred at 190¡ã C. for 5 h and then cooled at RT and diluted with 100 mL of CH2Cl2. The entire mixture was transferred onto a silica gel column and eluted with 20percent EtOAc/Hexane. The title compound was obtained as light-yellow solid (70 g, 69percent yield). 1H NMR (300 MHz, CDCl3): 1.26 (t, 3H), 3.74 (s, 2H), 4.15 (q, 2H), 6.87 (s, 1H), 77.25-7.86 (m, 10H); MassSpectrum (NH3-Cl): m/z 351 (M+1).

The synthetic route of 53266-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Butora, Gabor; Goble, Stephen D.; Pastemak, Alexander; Yang, Lihu; Zhou, Changyou; Moyes, Christopher R.; US2008/81803; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

20485-41-0, 4-Methylthiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 69 (250 mg, 0.81 mmol), HATU (460 mg, 1.2 mmol), dry N,N-dimethylformamide (5 mL), diisopropylethylamine (0.4 mL) and trimethylacetic acid (165 mg, 1.62 mmol) was stirred at room temperature for 12 h. The reaction mixture was poured into water (40 mL), extracted with ethyl acetate (3 x 30 mL), organic phases combined, washed with water (3 x 50 mL), a saturated aqueous solution of brine (20 mL), dried (magnesium sulfate), filtered and concentrated. The crude material was purified by Flashmaster II chromatography (eluent 0-90 percent ethyl acetate/dichloromethane). The purified material was taken up in diethyl ether (10 mL), washed with water (2 x 10 mL) to remove any trace N,N-dimethylformamide, dried (magnesium sulfate), filtered and concentrated to give 1-{4-[(4-Chloro-2-fluorophenyl)(pyridin-3-yl)methyl]piperazin-1-yl}-2,2-dimethylpropan-1-one (13) (53 mg, 17 percent) as a yellow oil.#10;, 20485-41-0

As the paragraph descriping shows that 20485-41-0 is playing an increasingly important role.

Reference£º
Article; Keenan, Martine; Alexander, Paul W.; Diao, Hugo; Best, Wayne M.; Khong, Andrea; Kerfoot, Maria; Thompson, R. C. Andrew; White, Karen L.; Shackleford, David M.; Ryan, Eileen; Gregg, Alison D.; Charman, Susan A.; Von Geldern, Thomas W.; Scandale, Ivan; Chatelain, Eric; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1756 – 1763;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

533-30-2, 6-Aminobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

533-30-2, General procedure: Dialkyl/diaryl phosphite (1.0 mmol) was added portion wise over a period of 5 min to the stirred mixture of heterocyclic aldehyde (1.0 mmol) and benzothiazole amine (1.0 mmol) at room temperature. Further 5 mol percent of TNT was added to the reaction mixture and the stirring was continued for 15 min. After the completion of the reaction as monitored through TLC, the reaction mixture was dissolved in EtOAc (2 mL) and the catalyst was separated by centrifugation followed by subsequent washings with EtOAc. The recovered catalyst was reused for the next cycle. The filtrate was washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated on a rotary evaporator and the resulting residue was purified by silica gel column chromatography (70:30, hexane/EtOAc) to afford the corresponding pure alpha-aminophosphonate. The novel alpha-aminophosphonates were structurally assigned by their IR, NMR (1H, 13C & 31P), and mass spectral (HRMS) analyses.

As the paragraph descriping shows that 533-30-2 is playing an increasingly important role.

Reference£º
Article; Reddy, Bhoomireddy Rajendra Prasad; Reddy, Motakatla Venkata Krishna; Reddy, Peddiahgari Vasu Govardhana; Kumar, Dharani Praveen; Shankar, Muthukonda V.; Tetrahedron Letters; vol. 57; 6; (2016); p. 696 – 702;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

944804-88-0, tert-Butyl 4-bromothiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

944804-88-0, A mixture of 48 (3.61g, 12.9mmol) and 70 Na2CO3 (3.4g, 32.3mmol) in DME/H2O/dioxane (240/48/48mL) was exchanged with N2 twice, and 5-chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (45a) (6.6g, 25.9mmol) and Pd(PPh3)4 (1.45g, 1.25mmol) were added to the mixture. The reaction mixture was heated to 100C and stirred for 6h under N2 atmosphere. The solid was removed by centrifugation at 3000rpm, 25C for 20min. The supernatant was concentrated and the crude product was purified by silica gel flash chromatography (eluting with ethyl acetate in petroleum ether 2-5%) to give 11 as a white solid (1.57g, yield=37%). 1H NMR (400MHz, DMSO-d6) delta 11.79 (s, 1H), 8.44 (s, 1H), 8.11 (s, 1H), 7.61 (s, 1H), 1.50 (s, 9H); LC/MS (ESI, m/z) 274.05 [M+H]+.

The synthetic route of 944804-88-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Beilei; Wu, Jiaxin; Wu, Yun; Chen, Cheng; Zou, Fengming; Wang, Aoli; Wu, Hong; Hu, Zhenquan; Jiang, Zongru; Liu, Qingwang; Wang, Wei; Zhang, Yicong; Liu, Feiyang; Zhao, Ming; Hu, Jie; Huang, Tao; Ge, Juan; Wang, Li; Ren, Tao; Wang, Yuxin; Liu, Jing; Liu, Qingsong; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 896 – 916;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22900-83-0,Ethyl 2-bromo-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Tert-Butyl 4- (2-benzyl) -4 (trifluoromethyl) phenyl) piperazine-1-carboxylate(0. 52 g, 1.50 mmol),Bromo-4-methylthiocono-5-carboxylate (0.39 g, 1. 58 mmol) and potassium carbonate(0.42 g, 3. OO mmol) was addedDMSO (10 mL), and the reaction was allowed to warm to 110 ¡ã C for 20 hours.After completion of the reaction, the reaction solution was cooled to room temperature,And water (20 mL) was added thereto, followed by extraction with ethyl acetate (20 mLX3). The combined organic phases were dried over anhydrous sodium sulphateDried, filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / v) = 2/1)Afforded the title compound as a light yellow solid (0.35 g, 45.2percent)., 22900-83-0

The synthetic route of 22900-83-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ru yuan yaozu zizhixian dazhong yaopin maoyi youxian co ltd/Ru yuan yaozu zizhixian dazhong yaopin maoyi youxian gongci; Jin, chuan Fei; Liang, Haiping; zhang, yingjun; Zhang, Ji; Kang, Ning; Li, Yong; Liu, Yan Ping; (38 pag.)CN105294554; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica