Month: October 2020

32955-22-9, Ethyl 5-thiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

K. 5-(Hydroxymethyl)thiazole To a precooled (ice bath) three neck 500 mL flask containing lithium aluminum hydride (76 mmol) in 250 mL of THF was added ethyl thiazole-5-carboxylate (11.82 g, 75.68 mmol) in 100 mL of THF dropwise over 1.5 hours to avoid excess foaming. The reaction was stirred for an additional hour, and treated cautiously with 2.9 mL of water, 2.9 mL of 15% NaOH, and 8.7 mL of water. The solid salts were filtered, and the filtrate set aside. The crude salts were heated at reflux in 100 mL of ethyl acetate for 30 min. The resulting mixture was filtered, and the two filtrates were combined, dried over Na2 SO4, and concentrated in vacuo. The product was purified by silica gel chromatography eluding sequentially with 0% – 2% – 4% methanol in chloroform, to provide the desired compound, Rf=0.3 (4% methanol in chloroform), which solidified upon standing in 75% yield. NMR (CDCl3) delta4.92 (s, 2H), 7.78 (s, 1 H), 8.77 (s, 1H). Mass spectrum: (M+H)+ =116., 32955-22-9

As the paragraph descriping shows that 32955-22-9 is playing an increasingly important role.

Reference£º
Patent; Abbott Laboratories; US5559158; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

73931-63-2, Methyl benzo[d]thiazole-6-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

73931-63-2, To a mixture of compound B-182 (5.0 g, 26 mmol) in anhydrous tetrahydrofuran (50 mL) was added DIBAL-H (50 mL, 1 .0 M in hexane) dropwise at -78 C. The mixture was stirred at -78 C for 2 hours. On completion, the reaction was quenched with water (50 mL) at 0 C and filtered, and the resulting filtrate was extracted with dichloromethane (3 x 100 mL). The combined organic layers were concentrated in vacuo to give compound B-183 (3.5 g, 81% yield) as a yellow oil.

As the paragraph descriping shows that 73931-63-2 is playing an increasingly important role.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.,41731-83-3

Synthesis of ethyl 2-piperazin-1-ylthiazole-5-carboxylate 1.02 g (5.0 mmol) of ethyl 2-bromothiazole-5-carboxylate and 4.31 g (50 mmol) of piperazine were dissolved in ethanol (20 ml) and the mixture was heated under reflux over a period of 4 h. The solution was then concentrated in vacuo, taken up in EA and washed successively with water and a satd aq. NaCl solution. Following drying of the organic phase over MgSO4, filtration and removal of solvent in vacuo there were obtained 1.12 g (4.6 mmol, 93%) of ethyl 2-piperazin-1-ylthiazole-5-carboxylate.

As the paragraph descriping shows that 41731-83-3 is playing an increasingly important role.

Reference£º
Patent; Gruenenthal GmbH; US2007/112011; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50850-93-6,Ethyl 2-aminobenzo[d]thiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

50850-93-6, Step 1: To a solution of tert-butyl nitrite (4.5 mL, 37.5 mmol) and copper(II) bromide (6.0 g, 27 mmol) in CH3CN(100 mL) at rt was added a mixture of ethyl 2-aminobenzo[d]thiazole-6-carboxylate (5.0 g, 22.5 mmol) in CH3CN (50mL). The reaction suspension was stirred at rt for 1 h. The resulting reaction mixture was quenched with 300 mL of 1 NHCl aqueous solution and extracted with CH2Cl2 (3×200 mL). The combined organic layers were dried over MgSO4,and concentrated under reduced pressure. The crude product was purified on a silica gel column using a mixture ofCH2Cl2-hexanes (4:1, v/v) as eluent to give ethyl 2-bromobenzo[d]thiazole-6-carboxylate as a white solid (6.2 g, 96%).1H NMR (300 MHz, CDCl3) delta 8.54 (d, J= 1.1 Hz, 1H), 8.16 (dd, J= 1.5, 8.7 Hz, 1H), 8.02 (d, J = 8.7 Hz, 1H), 4.43 (q, J=7.2 Hz, 2H), 1.43 (t, J= 7.2 Hz, 3H). LCMS (ESI) m/z 288, 286 (M+H)+.

As the paragraph descriping shows that 50850-93-6 is playing an increasingly important role.

Reference£º
Patent; Ambit Biosciences Corporation; HADD, Michael J.; HOCKER, Michael D.; HOLLADAY, Mark W.; LIU, Gang; ROWBOTTOM, Martin W.; XU, Shimin; (299 pag.)EP2766359; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-57-9,2-Amino-5-bromo-4-methylthiazole,as a common compound, the synthetic route is as follows.

2-Amino-5-bromo-4-trifluoromethylthiazole (0.8 g) was dissolved in 3 ml_ of 1 :1 mixture of THF and pyridine. 2,6-difluorobenzoylchloride (0.6 g) was added at room temperature with stirring. The mixture was stirred for 3 hours at room temperature. The mixture was poured into ice water and acidified with aqueous hydrochloric acid then extracted with chloroform. The organic layer was dried over Na2SO4 and the solvent was removed under reduced pressure. Flash chromatography on silica gel gave the title compound as a white solid. Yield 83percent.

3034-57-9, 3034-57-9 2-Amino-5-bromo-4-methylthiazole 12954373, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; SYNTA PHARMACEUTICALS CORP.; WO2007/87427; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-78-1,2-(Chloromethyl)thiazole,as a common compound, the synthetic route is as follows.

Step-(iii): A stirred solution of O (0.97 g, 6.46 mmol), G (1 g, 3.23 mmol) and potassium carbonate (1.33 g, 9.69 mmol) in dry DMF (10 ml) was degassed with nitrogen for 10 minutes. After 10 minutes Pd(dppf)2Cl2 (260 mg, 0.32 mmol) was added, again degassed with nitrogen for 10 minutes and the reaction mixture was stirred at 1 10C for 14 h. The progress of the reaction was monitored by TLC. After 14 h of stirring, the mixture was cooled to 20- 35C, diluted with water (100 ml) and extracted with ethyl acetate (2 x 100- ml). The combined organic layers were washed with brine (100 ml), followed by drying over anhydrous Na2SC>4 and filtering. The filtrate was rotary evaporated to get residue which was purified by column chromatography using a mixture of 30% ethyl acetate/hexane as an eluent to get the desired compound as a palebrown liquid (400 mg, 44%). NMR (400 MHz, DMSO-d6) delta 7.70 (d, J = 3.4 Hz, 1H), 7.60 (d, J = 3.5 Hz, 1H), 5.60 (s, 1H), 3.82 (s, 2H), 3.71 (s, 2H), 3.38 (t, J = 5.9 Hz, 2H), 2.06-1.96 (m, 2H), 1.40 (s, 9H)., 3364-78-1

3364-78-1 2-(Chloromethyl)thiazole 14090864, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana; WO2013/80222; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76874-79-8,2-Amino-4-chlorothiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

EXAMPLE 4; 16.3 parts of 2-amino-4-chloro-5-formylthiazole are dissolved in 100 parts of sulphuric acid 93% and admixed with 32 parts of nitrosylsulphuric acid 40% at 0 to 5C in the course of 30 minutes. This is followed by 3 hours of stirring in an icebath, and the diazonium salt solution is poured continuously into a mixture of 41.0 parts of phenylcarbonylmethyl 3- [N-allyl-N- (5′-acetylamino-2′-methoxy-phenylamino)]- propionate, 100 parts of glacial acetic acid, 2 parts of sulphamic acid and 300 parts of ice/water. The precipitated dye is filtered off, washed acid free with water and dried at 60C under reduced pressure. The dye obtained, which has Amax = 625 (DMF), conforms to the formula and dyes polyester materials in greenish navy shades and is useful as individual dye or in navy and black mixtures for the eForon RD rapid-dyeing process, with very good fastnesses, 76874-79-8

As the paragraph descriping shows that 76874-79-8 is playing an increasingly important role.

Reference£º
Patent; CLARIANT INTERNATIONAL LTD; WO2005/56690; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22900-83-0,Ethyl 2-bromo-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Part F: Ethyl 4-methyi-2-morpholin-4-yl-1.3-thiazole-5-carboxylate; A mixture of ethyl 2-bromo-4-methyl-ls3-thiazole-5-carboxylate (950 mg, 3.80 mmol), morpholine (0.5 mL, 5.70 mmol), and potassium carbonate (1.1 g, 7.60 mmol) in 4.0 ml of NMP is heated to 130 ¡ãC for 1.5 h. The reaction is cooled to RT, and the NMP is removed in vacuo. The residue is partitioned between CH1CI2 and water (20 ml each), and the layers are separated. The aqueous layer is extracted once more with 20 ml of CH2CI2, and the combined organic extracts are dried (Na2SQ4), filtered, and evaporated in vacuo to give the title compound as an off-white solid. Mass spec. (257.06, M+H)., 22900-83-0

22900-83-0 Ethyl 2-bromo-4-methylthiazole-5-carboxylate 2824057, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; NEUROGEN CORPORATION; WO2008/83070; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.399-74-6,2-Chloro-6-fluorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

Example 3: N-[(/5^25)-2-[(6-Fluoro-l<3-benzothiazol-2-vl)amino1cvclopentyl1-2<6- dimethoxybenzamide A microwave vial was charged N-((iS,2S)-2-aminocyclopentyl)-2,6-dimethoxybenzamide hydrochloride (Intermediate 11; 80 mg, 0.266 mmol), DIPEA (0.26 ml, 0.266 mmol) and 2-chloro-6-fluoro-l,3-benzothiazole (50 mg, 0.266 mmol) and the resulting mixture was heated with microwave irradiation at 250 C for 20 minutes. The reaction was purified by reverse phase preparative HPLC eluted with acetonitrile / water (with 0.1% ammonia) to afford the title compound.1H NMR (DMSO- e) delta ppm 1.48 - 1.77 (m, 4 H), 2.02 - 2.14 (m, 2 H), 3.62 (s, 6 H), 4.09 - 4.27 (m, 2 H), 6.51 - 6.65 (m, 2 H), 7.03-7.05 (m, 1 H), 7.18 - 7.38 (m, 2 H), 7.59 (m, 1 H) and 8.12-8.15 (m, 2 H)MS ES+: 416 399-74-6, The synthetic route of 399-74-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1477-42-5, 4-Methylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add commercially available 2-amino-4-methy-benzothiazole (10 g, 61 mmol) portionwise to a black solution of copper (II) bromide (16 g, 73 mmol) and TERT-BUTYL nitrite (11.9 mL, 99 mmol) in acetonitrile (220 mL) at room temperature under nitrogen over the course of five min and stir the mixture for 30 min. Dilute the mixture with 1 N HCL (500 mL) and extract with ethyl acetate (3 x 500 mL). Wash the combined organic extracts with 1 N HCL (250 mL), dry over MGS04 and remove the solvents under reduced pressure. Purify the residue by filtration through a plug of silica gel, eluting with ethyl acetate (500 mL), and remove the solvents under reduced pressure to afford 2-bromo-4-methylbenzothiazole (Step 1) as a black solid (12.68 g, 91%): 1H NMR (CDCL3) 6 2.70 (s, 1H), 7.20 (m, 2H), 7.60 (d, 1H) ; APCI mass spectrum M/Z 228 [C8H6NSBR + H] +., 1477-42-5

As the paragraph descriping shows that 1477-42-5 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/63155; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica