Day: November 4, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69812-29-9,2-Acetamido-4-methylthiazole-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.

[00217] A solution of 3-(10,l l-dihydro-5H-dibenzo[?/]azepin-5-yl)propan-l-amine hydrochloride (0.075 g, 0.259 mmol) in DMF (0.85 mL) was cooled to 0 C, treated with Et3N (0.144 mL, 1.03 mmol), and 2-acetamido-4-methylthiazole-5-sulfonyl chloride (0.073 g, 0.285 mmol). The mixture was warmed to 25 C and stirred for 2 h. The mixture was partitioned between water (50 mL) and CH2CI2 (50 mL). The organic layer was washed with saturated aqueous NaCl (5 x 30 mL), dried (Na2S04), and concentrated in vacuo. The residue was dissolved in a minimal amount of CH2CI2 and purified by flash chromatography (S1O2, 2-5% ethyl acetate -hexanes) to afford the title compound (0.032 g, 26%) as a white solid. 1H NMR (600 MHz, CD3OD) delta 7.10- 7.01 (6H, m), 6.88-6.85 (2H, m), 3.71 (2H, t, J= 6.6 Hz), 3.02 (3H, br s), 2.99 (2H, J = 6.6 Hz), 2.36 (3H, s), 2.23 (3H, s), 1.71 (2H, quintet, J= 6.6 Hz); 13C NMR (150 MHz, CD3OD) delta 169.8, 159.2, 151.7, 148.2, 134.2, 129.5, 126.1, 12.4, 119.6, 119.5, 46.9, 40.5, 31.9, 27.2, 21.2, 15.0; LCMS m/z 471.2135 ([M + H+], C23H27N4O3S2 requires 471.1519).

69812-29-9, As the paragraph descriping shows that 69812-29-9 is playing an increasingly important role.

Reference£º
Patent; MT. SINAI SCHOOL OF MEDICINE; OHLMEYER, Michael; NARLA, Goutham; DHAWAN, Neil; KASTRINSKY, David; WO2013/25882; (2013); A2;,
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Thiazole | chemical compound | Britannica

18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Amino-thiazole-4-carboxylic acid ethyl ester (460 mg) obtained in the same manner as in Chem. Pharm. Bull, 19(1) 119-123 (1971) was dissolved in ethanol (7 ml). Hydrazine monohydrate (1.3 ml) was added to this solution and the mixture was refluxed at 100C for 22 hr. The reaction mixture was cooled to room temperature and the obtained solid was collected by filtration and washed with ethanol. This solid was dried in vacuo to give the title compound (280 mg).1H-NMR(?, 300MHz, DMSO-d6) 4.26(2H,s),7.07(2H,s),8.00(1H,s),8.83(1H,s)., 18903-18-9

The synthetic route of 18903-18-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Japan Tobacco Inc.; EP1452526; (2004); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14542-12-2,Thiazol-2-ylmethanol,as a common compound, the synthetic route is as follows.,14542-12-2

This material (3.4 g, 29.6 mmol, 1 eq) was treated with TBDPSCI (8.94 g, 1.1 eq),imidazole (4.0 g, 2 eq) in 20 mL DCM. The mixture was stirred for 14 h. After removalof solvent, extraction with EtOAc and drying the organic layer with Na2C03,evaporation of the solvent afforded 10.5 g of the desired product quantitavely.1HNMR(CDCI35): 1.1 (s, 9 H) 4.90.(s, 2H) 7.30-7.40 (m, 7 H) 7.60-7.70 Patent; SCHERING CORPORATION; WO2006/19957; (2006); A2;,
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Thiazole | chemical compound | Britannica

78364-55-3, 6-Fluoro-2-hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78364-55-3

General procedure: A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized to give compounds 3-29.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
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Thiazole | chemical compound | Britannica

848841-68-9, 4-(4-Chlorothiazol-2-yl)morpholine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,848841-68-9

Method B; N- { 4-Chloro-5-[8-( 1 -ethyl-propyl)-2,6-dimethyl-imidazo [1,2- b]pyridazin-3-yl]-thiazol-2-yl } -morpholine.; A 20L reactor flask under nitrogen is charged with 2900 ml of dry and degassed DMF then with 8-(1-ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine (287 g, 0.836 mol), 2-morpholino-4-chlorothiazole (205.4 g, 1.01 mol, 1.2 equv.), Pd(OAc)2 (3.74 g, 7.91 mmol, 0.01 equiv.), triphenylphosphine (8.77g, 33.1 mmol, 0.04 equiv.), Copper iodide (8 g, 41.59 mmol, 0.05 equiv.) and cesium carbonate (544.9 g, 1.65 mol). The reaction mixture is heated at 120C. After 16 h at 120C, 1.87 g of Pd(OAc)2 and 4.38 g of triphenylphosphine more is added. After 1 h, the mixture is cooled, quenched with NH4CI solution (4300 mL) and extracted with MTBE (2900 mL), the aqueous phase is extracted twice more with 2000 ml of MTBE. The organic phases are washed with sat NaCl aq (2000 mL), then treated with charcoal 72 g in flask bottle and filtered on Celite. The filtrate is concentrated under vacuum to afford 373.8 g (79.3%) of the title compound which is 81.4%-area HPLC analysis the rest being solvent and with no detectable Example 200 by-product.

The synthetic route of 848841-68-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2006/102194; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56354-98-4,6-Aminobenzo[d]thiazol-2(3H)-one,as a common compound, the synthetic route is as follows.,56354-98-4

General procedure: To a stirred suspension of benzo [d]oxazol-2(3H)-one derivative,or benzimidazole, or 2H-benzo [b] [1,4]oxazin-3(4H)-one(1.0 mmol), anhydrous K2CO3 (1.2 mmol) was added in the DMFsolvent for 20 min at 70 C. Then bromoacetylated 1a-1f or 2a-2c(1.3 mmol) and TBAI (0.1 mmol) were added simultaneously. Thereaction was stirred and heated for 4 h. After completion, themixture was extracted with EtOAc/H2O three times. The combinedorganic layers were washed with brine, dried over anhydrousNa2SO4, filtered and concentrated under reduced pressure. Thecrude product was purified by silica gel column chromatographyeluting with EtOAc/PE (3:1e8:1) to afford compounds B01-B29,C01-C03.

As the paragraph descriping shows that 56354-98-4 is playing an increasingly important role.

Reference£º
Article; Yang, Lixin; Liu, Yongqing; Fan, Minghua; Zhu, Guiwang; Jin, Hongwei; Liang, Jing; Liu, Zhenming; Huang, Zhuo; Zhang, Liangren; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19759-66-1,2-Aminobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.

General procedure: To a solution of thiophene-2-carbonyl chloride (2a) or3-chlorothiophene-2-carbonyl chloride (2b) in dry tolueneor DMF, corresponding anilines and amino-pyridines 1a-1f, 2-amino-6-subtituted-benzimidazoles 10a-10c, or2-amino-6-substituted-benzothiazoles 10d-10f were added,followed by the addition of Et3N. The mixture was refluxedfor several hours. After cooling, the resulting products werefiltered off and washed with diluted HCl and recrystallizatedfrom ethanol/DMF to obtain heteroaromaticcarboxamides 3a-3f and 11a-11h.

19759-66-1, The synthetic route of 19759-66-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sovi, Irena; Viski, Marko; Bertoa, Branimir; Ester, Katja; Kralj, Marijeta; Hranjec, Marijana; Karminski-Zamola, Grace; Monatshefte fur Chemie; vol. 146; 9; (2015); p. 1503 – 1517;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isatin (5 mmol) was dissolved in methanol (40 mL), and corresponding reactants(amine (R-NH2, 5 mmol) and glacial acetic acid (1 mL) in the given order) were added.Reaction mixture was refluxed at 70 C for 6 h under stirring at atmospheric pressure.ubsequently, the mixture was left overnight without stirring at room temperature. Theobtained crystals were filtered off, dried and recrystallized from methanol. On average, theyield was about 70-79 % (details are given in the Supplementary material)., 121-66-4

The synthetic route of 121-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; ?ekularac, Gavrilo M.; Nikoli?, Jasmina B.; Petrovi?, Predrag; Bugarski, Branko; Durovi?, Boban; Drmani?, Sa?a ?.; Journal of the Serbian Chemical Society; vol. 79; 11; (2014); p. 1347 – 1354;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

615-21-4, In a three-neck reactor equipped with a thermometer,In a nitrogen stream,10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 150 ml of DMF.To this solution,39.4 g (121.0 mol) of cesium carbonate was added and the mixture was cooled to 0 C.,16.4 g (72.5 mmol) of iodoheptane was added dropwise over 5 minutes,After completion of the dropwise addition, the whole contents were stirred at 25 C. for 3 hours.After completion of the reaction, 1000 ml of water was added to the reaction solution,And extracted twice with 500 ml of ethyl acetate.After drying the organic layer with anhydrous sodium sulfate,Sodium sulfate was filtered off.After concentrating the filtrate with a rotary evaporator,The concentrate was purified by silica gel column chromatography (n-hexane: ethyl acetate = 85: 15)9.05 g of Intermediate P was obtained as a white solid (yield 56.9%).

The synthetic route of 615-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (77 pag.)JP2017/206554; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

155559-81-2, 5-Fluorobenzo[d]thiazole-2-thiol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 4?-demethylepipodophyllotoxin (DMEP) (400mg 1mmol) and SH-containing building blocks in dichloromethane (15mL) at 0C was mixed with 1mL of TFA as the catalyst. After stirring the reaction mixture for 2-3hat room temperature and maximal conversion was reached (3h, monitored by TLC), the resultant mixture was washed with saturated NaHCO3 (20mL¡Á2) and extracted with CH2Cl2 (45mL¡Á2). The organic layer was dried over MgSO4, and the solvent was evaporated to give a crude residue, which was purified by flash column chromatography (petroleum ether: dichloromethane: ethyl acetate, 3:2:1) to afford the target compounds. The purity of compounds was determined by HPLC with a thermo-C18 (250mm¡Á4.6mm, 5mum) column as the stationary phase and methanol-water (35:65) as the mobile phase at ambient temperature and a flow rate of 2.0mL/min., 155559-81-2

155559-81-2 5-Fluorobenzo[d]thiazole-2-thiol 2774531, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Qing-Yun; Zhao, Wei; Tang, Ya-Jie; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 951 – 964;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica