Downstream synthetic route of 121-66-4

The synthetic route of 121-66-4 has been constantly updated, and we look forward to future research findings.

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isatin (5 mmol) was dissolved in methanol (40 mL), and corresponding reactants(amine (R-NH2, 5 mmol) and glacial acetic acid (1 mL) in the given order) were added.Reaction mixture was refluxed at 70 C for 6 h under stirring at atmospheric pressure.ubsequently, the mixture was left overnight without stirring at room temperature. Theobtained crystals were filtered off, dried and recrystallized from methanol. On average, theyield was about 70-79 % (details are given in the Supplementary material)., 121-66-4

The synthetic route of 121-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; ?ekularac, Gavrilo M.; Nikoli?, Jasmina B.; Petrovi?, Predrag; Bugarski, Branko; Durovi?, Boban; Drmani?, Sa?a ?.; Journal of the Serbian Chemical Society; vol. 79; 11; (2014); p. 1347 – 1354;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica