With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19759-66-1,2-Aminobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.
General procedure: To a solution of thiophene-2-carbonyl chloride (2a) or3-chlorothiophene-2-carbonyl chloride (2b) in dry tolueneor DMF, corresponding anilines and amino-pyridines 1a-1f, 2-amino-6-subtituted-benzimidazoles 10a-10c, or2-amino-6-substituted-benzothiazoles 10d-10f were added,followed by the addition of Et3N. The mixture was refluxedfor several hours. After cooling, the resulting products werefiltered off and washed with diluted HCl and recrystallizatedfrom ethanol/DMF to obtain heteroaromaticcarboxamides 3a-3f and 11a-11h.
19759-66-1, The synthetic route of 19759-66-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Sovi, Irena; Viski, Marko; Bertoa, Branimir; Ester, Katja; Kralj, Marijeta; Hranjec, Marijana; Karminski-Zamola, Grace; Monatshefte fur Chemie; vol. 146; 9; (2015); p. 1503 – 1517;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica