440100-94-7, 2-Bromothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 2-bromothiazole-5-carbonitrile (259 mg, 1.37 mmol), 6-phenylpiperidin-2-one (200 mg, 1.14 mmol), cesium carbonate (558 mg, 1.71 mmol), XantPhos (52.8 mg, 0.091 mmol),and Pd(Ph3P)4 (132 mg, 0.114 mmol) in dioxane (3 mL) in a sealed tube was heated at 125 C for 18 h under N2. The reaction mixture was cooled to room temperature and partitioned between water (20 mL) and ethyl acetate (30 mL x 2). The combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by reverse-phase prep-HPLC (preparative HPLC on a GILSON 281 instrument fitted with Waters XSELECT C18 l5Ox3Ommx5um using water and acetonitrile as the eluents, mobile phase A:water, mobile phase B: acetonitrile (containing: 0.1%TFA-ACN), gradient: 38-68%, 0-10 mm; 100% B, 10.5-12.5 mm; 5% B, 13-15 mm) to give 2-(2-oxo-6-phenylpiperidin-1-yl)thiazole-5- carbonitrile as a solid. ESI-MS m/z [M+Hf?: 284.0.
440100-94-7, 440100-94-7 2-Bromothiazole-5-carbonitrile 17860952, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; WALJI, Abbas; BERGER, Richard; STUMP, Craig, A.; SCHLEGEL, Kelly Ann, S.; MULHEARN, James, J.; GRESHOCK, Thomas, J.; GINNETTI, Anthony, T.; WANG, Deping; STACHEL, Shawn, J.; FRALEY, Mark, E.; (87 pag.)WO2017/222950; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica