Day: November 6, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.777-12-8,6-(Trifluoromethyl)benzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

777-12-8, To a stirred solution of methyl 5-chloro-2-methoxy-3-((methoxymethoxy)methyl)benzoate (122mg, 0.445mmo1) in MeOH (5m1) was added 2.2 ml iN KOH solution. The resulting mixture was stirred at 60¡ãC overnight. After cooled to rt, the reaction was partitioned between EA and 2percent citric acid. The EA layer was washed with brine, dried over Na2504 and concentrated in vacuo. To this residue was added HBTU (98mg, 0.258mmo1), DMF (3m) and DIPEA (187u, 1.075 mmo). The mixture was stirred for lOmins and then 6-(trifluoromethy)benzo[d]thiazo-2-amine (47mg, 0.2l5mmo) was added. The resuting reaction was heated at 120 ¡ãC for 24hs. After cooed to rt, the mixture was separated between EA and water. The organic ayer was washed with brine, dried over Na2SO4 and concentrated in vacuo. Purification by coumn chromatography gave the 5- choro-2-hydroxy-3 -((methoxymethoxy)methy)-N-(6-(trifluoromethy)benzo[d]thiazo -2y)benzamide as a yeow soid (37mg, 39percent). ?H NMR (400 MHz, Choroform-d) 8.16 (s, 1H), 7.99 (d, J = 2.5 Hz, 1H), 7.91 (d, J = 6.1 Hz, 1H), 7.72 (d, J = 6.1 Hz, 1H), 7.48 (d, J =2.5 Hz, 1H), 4.80 (s, 2H), 4.78 (s, 2H), 3.47 (s, 3H). MS (ESI) [M+Na] requires m/z 469.02, found m/z 468.55.

777-12-8 6-(Trifluoromethyl)benzo[d]thiazol-2-amine 2735955, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; JIN, Shengkan; AUGERI, David J.; CAO, Bin; TAO, Hanlin; (126 pag.)WO2017/201313; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

Hydroxylamine hydrochloride (9.03 g, 130 mmol) was added to a solution of 1 ,3-thiazole-2-carbaldehyde (14.71 g, 130 mmol) and pyridine (10.5 mL, 130 mmol) in DCM (100 mL). The reaction mixture was stirred overnight at room temperature and then washed twice with water. The organic layer was dried over MgS04 and then evaporated under reduced pressure to give 15.26 g of 1 ,3-thiazole-2-carbaldehyde oxime (yield 92percent)., 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE – CNRS -; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); INSTITUT PASTEUR DE LILLE; DEPREZ, Benoit; WILLAND, Nicolas; FLIPO, Marion; DESROSES, Matthieu; BAULARD, Alain; LEROUX, Florence; WO2013/60744; (2013); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

38585-74-9, Thiazol-5-ylmethanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

REFERENCE EXAMPLE 50 2-Fluoro-4-(thiazol-5-ylmethoxy)benzonitrile Diisopropylazodicarboxylate (4.0 g) was dissolved in a little anhydrous tetrahydrofuran (about 10 ml) and added dropwise to a stirred solution of triphenylphosphine (5.2 g) in anhydrous tetrahydrofuran (150 ml) at 0 C. under nitrogen. After stirring at 0 C. for 15 minutes, during which time a white precipitate formed, a mixture of 2-fluoro-4-hydroxybenzonitrile (S. M. Kelly, Helv.Chim.Acta. 1984, Volume 67, P.1572-1579) (2.0 g) and thiazole-5-methanol (2.3 g) in anhydrous tetrahydrofuran (20 ml) was added dropwise whilst maintaining the temperature at or below 5 C. The reaction mixture was stirred in the cooling bath for a further 2 hours then allowed to warm slowly to room temperature. After standing at room temperature overnight the reaction mixture was partitioned between ethyl acetate (200 ml) and saturated aqueous ammonium chloride solution (200 ml). The layers were separated and the organic phase washed with water (100 ml), dried over magnesium sulphate and evaporated. The residue was purified by flash chromatography on silica eluding with a mixture of ethyl acetate and cyclohexane (1:1, v/v). Fractions homogenous in the required product were combined and evaporated affording the title compound as a pale yellow solid (2.0 g).

38585-74-9, As the paragraph descriping shows that 38585-74-9 is playing an increasingly important role.

Reference£º
Patent; Rhone-Poulenc Rorer Limited; US6124343; (2000); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64485-82-1,(Z)-Ethyl 2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetate,as a common compound, the synthetic route is as follows.

Example 33; (Z)-5-benzo[d]thiazol-2-yl-2-(5-(trifluoromethyl)-2-(tritylamino)thiazol-4-yl)-2-(trityloxyimino)ethanethioate; Step 1 : To a solution of 1 (43 g, 0.2 moL) in 300 mL DMF was added 63 mL TEA. The mixture was stirred for 10 min, then 123 g of trityl chloride was added and the mixture was kept at 50 0C for 72 hrs. The mixture was concentrated and extracted with acetic ether. The acetic ether was washed with 1% NaOH solution three times, the organic layer was dried over Na2SO4, filtered and the filtrate was concentrated under reduced pressure. The residue was dried in vacuum overnight to provide (Z)-ethyl-2-(2-(tritylamino)thiazol-4-yl)-2-(trityloxyimino)acetate 2 (120 g, yield 85%).

64485-82-1, The synthetic route of 64485-82-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ACHAOGEN, INC.; WAGMAN, Allan, Scott; MOSER, Heinz, Ernst; WO2010/30811; (2010); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

161798-03-4, Example 3Preparation of 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (FBZC)To a 500 ml three-necked bottle was added 28.0 g of ethyl 2-[3-formyl-4-(2-methyl propoxy)phenyl]-4-methyl-5-thiazolcarboxylate, 280 ml of 10% sodium hydroxide solution and 90 ml of ethanol, the reaction was performed under stirring at about 80 C. for about 4 h, then the reaction stopped, cooled, adjusted by adding dropwise slowly a concentrated hydrochloride to about pH 3. A white solid was precipitated and filtered. The filter cake was washed with water, and dried by vacuum sucking. The filter cake was recrystallized with ethyl acetate, filtered, then dried at 70-75 C. in a reduced pressure (-0.080 to -0.085 MPa) to obtain 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (FBZC) (11.2 g) as a white crystalline. Purity (by HPLC): 99%. IR (KBr): 3432, 2966, 2871, 1679, 1652, 1605, 1513, 1447, 1427, 1371, 1179, 1111, 1014 cm-1. 1H-NMR (500 MHz, DMSO-d6) delta (ppm): 13.360 (1H, s), 10.397 (1H, s), 8.191-8.153 (2H, m), 7.337-7.319 (1H, d), 3.990-3.977 (2H, d), 2.659 (3H, s), 2.163-2.084 (1H, s), 1.045-1.031 (6H, d).

161798-03-4 Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 10904158, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO/. LTD.; US2011/282069; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

615-21-4, 2-Hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,615-21-4

Into a four-necked reactor equipped with a thermometer,In a nitrogen stream,5.0 g (30.3 mmol) of 2-hydrazinobenzothiazole was added,Was dissolved in 100 ml of DMF.To this solution were added 20.9 g (152 mmol) of potassium carbonate,5.17 g (30.3 mmol) of 5-bromovaleronitrile was added,And the mixture was stirred at 60 C. for 8 hours.After completion of the reaction,The reaction solution was cooled to 20 C.,The reaction solution was poured into 500 mL of water,And extracted with 500 ml of ethyl acetate.The ethyl acetate layer was dried over anhydrous sodium sulfate.After filtering off sodium sulfate,Ethyl acetate was distilled off under reduced pressure on a rotary evaporator to obtain a yellow solid. This yellow solid was purified by silica gel column chromatography (n-hexane: ethyl acetate = 60: 40) to obtain 3.41 g of Intermediate J (yield: 45.7 mol%) as a white solid

As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; KIRIKI, SATOSHI; (84 pag.)JP2017/206504; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6436-59-5,Ethyl 2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

A solution of ethyl 2-methylthiazole-4-carboxylate (1.00 g, 5.8 mmol) in toluene (18 mL) at -78 C. was treated dropwise with a diisobutyl aluminum hydride solution in dichloromethane (11.1 mL, 1 M) over 30 minutes, stirred at -78 C. for 4 hours, quenched with acetic acid (0.46 mL), warmed to 25 C. and concentrated. The concentrate was treated with dichloromethane and Rochelle’s salt, stirred vigorously until a clear, two-phase solution formed (approximately 10 minutes). The layers were separated and organic layer was washed with 10% NaHCO3, brine, dried over Na2SO4, filtered and concentrated. The residue was chromatographed on silica gel, eluting with 14% ethyl acetate in hexanes to give the title compound (0.28 g, 38% yield)., 6436-59-5

6436-59-5 Ethyl 2-methylthiazole-4-carboxylate 293353, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; DeGoey, David A.; Flentge, Charles A.; Flosi, William J.; Grampovnik, David J.; Kempf, Dale J.; Klein, Larry L.; US2005/131017; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

944804-88-0, tert-Butyl 4-bromothiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 51 (0.5g, 1.8mmol), 48 (0.381g, 2.7mmol) and triphenylphosphine (0.707g, 2.7mmol) in anhydrous THF (20mL) at 0C was added diisopropyl azodicarboxylate (DIAD) (0.545g, 2.7mmol) dropwise. The reaction mixture was allowed to stir at room temperature for 10min and then stirred at 40C overnight. The resulting mixture was concentrated and the residue was purified by silica gel flash chromatography (eluting with ethyl acetate in 74 petroleum ether 2-5%) to give the 172 product 52a as a white solid (0.365g, yield=50%)., 944804-88-0

As the paragraph descriping shows that 944804-88-0 is playing an increasingly important role.

Reference£º
Article; Wang, Beilei; Wu, Jiaxin; Wu, Yun; Chen, Cheng; Zou, Fengming; Wang, Aoli; Wu, Hong; Hu, Zhenquan; Jiang, Zongru; Liu, Qingwang; Wang, Wei; Zhang, Yicong; Liu, Feiyang; Zhao, Ming; Hu, Jie; Huang, Tao; Ge, Juan; Wang, Li; Ren, Tao; Wang, Yuxin; Liu, Jing; Liu, Qingsong; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 896 – 916;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

61296-22-8, [00156] Di-tert-butyl dicarbonate (28.90 g, 132.4 mmol) was added portionwise to a suspension of 2-amino-5-bromothiazole monohydrobromide (28.64 g, 110.3 mmol) in pyridine (100 mL) over 20 minutes at room temperature. The mixture was stirred at room temperature overnight. The solvent was evaporated. The residue was extracted between 0.5 N HCl (200 mL) and ethyl acetate (200 mL). The organic layer was separated and concentrated. The residue was filtered through a pad of silica gel using 10% ethyl acetate/hexane as a solvent. The filtrate was concentrated to give tert-butyl-5-bromothiazol-2-ylcarbamate (19.5 g, 63% yield) as a white solid. LCMS (Conditions A): 3.40 min (RT); (M+H)+ = 225.12 (100%), 223.12 (95%). 1H NMR, 400 MHz, CDCl3: delta 7.27 (s, 1 H), 1.60 (s, 9 H).

61296-22-8 2-Amino-5-bromothiazole monohydrobromide 2723848, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/155389; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2289-75-0,4,5-Dimethylthiazol-2-amine,as a common compound, the synthetic route is as follows.

e. N-(4,5-Dimethyl-2-thiazolyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide, m.p. 264-265 C (decomp., from ethylene chloride), from 2-methyl-4-(1-pyrrolidyl)-2-H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid chloride-1,1-dioxide and 2-amino-4,5-dimethyl-thiazole.

2289-75-0, As the paragraph descriping shows that 2289-75-0 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim GmbH; US3992535; (1976); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica