With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
161798-03-4, Example 3Preparation of 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (FBZC)To a 500 ml three-necked bottle was added 28.0 g of ethyl 2-[3-formyl-4-(2-methyl propoxy)phenyl]-4-methyl-5-thiazolcarboxylate, 280 ml of 10% sodium hydroxide solution and 90 ml of ethanol, the reaction was performed under stirring at about 80 C. for about 4 h, then the reaction stopped, cooled, adjusted by adding dropwise slowly a concentrated hydrochloride to about pH 3. A white solid was precipitated and filtered. The filter cake was washed with water, and dried by vacuum sucking. The filter cake was recrystallized with ethyl acetate, filtered, then dried at 70-75 C. in a reduced pressure (-0.080 to -0.085 MPa) to obtain 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (FBZC) (11.2 g) as a white crystalline. Purity (by HPLC): 99%. IR (KBr): 3432, 2966, 2871, 1679, 1652, 1605, 1513, 1447, 1427, 1371, 1179, 1111, 1014 cm-1. 1H-NMR (500 MHz, DMSO-d6) delta (ppm): 13.360 (1H, s), 10.397 (1H, s), 8.191-8.153 (2H, m), 7.337-7.319 (1H, d), 3.990-3.977 (2H, d), 2.659 (3H, s), 2.163-2.084 (1H, s), 1.045-1.031 (6H, d).
161798-03-4 Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 10904158, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO/. LTD.; US2011/282069; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica