With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64485-82-1,(Z)-Ethyl 2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetate,as a common compound, the synthetic route is as follows.
Example 33; (Z)-5-benzo[d]thiazol-2-yl-2-(5-(trifluoromethyl)-2-(tritylamino)thiazol-4-yl)-2-(trityloxyimino)ethanethioate; Step 1 : To a solution of 1 (43 g, 0.2 moL) in 300 mL DMF was added 63 mL TEA. The mixture was stirred for 10 min, then 123 g of trityl chloride was added and the mixture was kept at 50 0C for 72 hrs. The mixture was concentrated and extracted with acetic ether. The acetic ether was washed with 1% NaOH solution three times, the organic layer was dried over Na2SO4, filtered and the filtrate was concentrated under reduced pressure. The residue was dried in vacuum overnight to provide (Z)-ethyl-2-(2-(tritylamino)thiazol-4-yl)-2-(trityloxyimino)acetate 2 (120 g, yield 85%).
64485-82-1, The synthetic route of 64485-82-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ACHAOGEN, INC.; WAGMAN, Allan, Scott; MOSER, Heinz, Ernst; WO2010/30811; (2010); A2;,
Thiazole | C3H3NS – PubChem
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