Day: November 9, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90533-23-6,4-(3-Chlorophenyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.,90533-23-6

Step 3:; To a solution of 4-(3-chlorophenyl)thiazol-2-amine (1 g) in tetrahydrofuran (20 mL) was added NBS (0.88 g). After stirring at room temperature overnight, the mixture was partitioned between ethyl acetate (30 mL) and water (20 mL). The organic phase was washed with water (20 mL x 2), dried and concentrated to give 5-bromo-4-(3-chlorophenyl)thiazol-2-amine (1.05 g) as a red liquid. MS(ES ) m/z 289 (MH ).

90533-23-6 4-(3-Chlorophenyl)thiazol-2-amine 675261, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting; WO2012/100734; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of compound 1 (7.8 g, 45.3mmol), Boc2O (9.9 g, 45.3 mmol), DMAP (0.1 g, 0.82mmol) in CH2Cl2 (50 mL) was stirred at room temperature for 4 h. After completion of the reaction, the mixture was washed with H2O (30mL), brine (30 mL), the organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude product was purified by column chromatograph on silica gel (200-300 mesh) by ethyl acetate and petroleum ether (v/v = 1:2) as eluent to afford 2 as a light yellow solid (11.5 g, yield 93.5%).

5398-36-7, The synthetic route of 5398-36-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Feng-Yun; Guo, Xiao-Feng; Fan, Zhi-Jin; Zhang, Yu-Qing; Zong, Guang-Ning; Qian, Xiao-Lin; Ma, Liu-Yong; Chen, Lai; Zhu, Yu-Jie; Tatiana, Kalinina; Morzherin, Yury Yu.; Belskaya, Nataliya P.; Chinese Chemical Letters; vol. 26; 10; (2015); p. 1315 – 1318;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

39136-63-5, 5-Phenylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: (3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate To 5-phenylthiazol-2-amine (0.52 g, 2.9 mmol) in acetonitrile (6 mL) was added Iota, Gamma-thiocarbonyldiimidazole (0.68 g, 3.8 mmol). The reaction mixture was stirred at 65 C for 2 hours. The precipitate was filtered and washed with acetonitrile (2 x 20 mL) to yield intermediate N-(5-phenylthiazol-2-yl)- ^-imidazole-l- carbothioamide. The intermediate was taken up in N,N-dimethylformamide (30 mL) and treated with (3-(aminomethyl)-3-hydroxy-l-ammoniobicyclo[2.2.2]octan-l- yl)trihydroborate (0.5 g, 2.9 mmol). The reaction mixture was stirred for 5 hours at 65 C. The reaction was concentrated in vacuo and purified via silica gel chromatography (30-100% ethyl acetate/hexane). The product fractions were combined and concentrated in vacuo to yield (3-hydroxy-3-((3-(5-phenylthiazol-2- yl)thioureido)methyl)-l-ammoniobicyclo[2.2.2]octan-l-yl)trihydroborate (.85 g, 2.19 mmol, 74.4 % yield) as a white powder. LC/MS confirmed product with loss of BH3 in the LC/MS conditions: retention time 3.26 (M+1-BH3= 375.33)., 39136-63-5

39136-63-5 5-Phenylthiazol-2-amine 873119, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.; WO2011/53292; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Method A [31]: To a solution of the starting aldehyde (1.5 mmol) and ketone (0.75 mmol) in methanol (10 mL) was added the solution of sodium methoxide in methanol (5.4 M, 0.14 mL,0.75 mmol), and the mixture was stirred for 4-18 h and monitored with TLC. When the reaction was completed, the following two work-up procedures were applied. Procedure 1: if precipitate was observed, the precipitate was filtered and rinsed with cold methanol. Procedure 2: if no precipitate was observed, then saturated solution of ammonium chloride was added, and the subsequent mixture was extracted with dichloromethane. The organic layer was dried over anhydrous MgSO4. The solvent was evaporated under vacuum to give a crude product, which was purified by preparative TLC (3e5percent methanol in dichloromethane) or column chromatography (2percent methanol in dichloromethane)., 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Article; Samaan, Nawras; Zhong, Qiu; Fernandez, Jayjoel; Chen, Guanglin; Hussain, Ali M.; Zheng, Shilong; Wang, Guangdi; Chen, Qiao-Hong; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 123 – 131;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: Dry sodium nitrite (1.04 g, 15 mmol) was slowly added with stirring to cold concentrated sulphuric acid (10 ml) and warmed to 50 C on water bath. The solution was then cooled to 0 C and a mixture of glacial acetic acid/propionic acid (30 ml, 5:1) was added dropwise with stirring so as to maintain the temperature below 15 C. The resulting solution was then cooled below 0 C and to this, 2-amino-5-nitrothiazole (2.17 g, 15 mmol) was added in small portions while stirring. The stirring was further continued at this temperature for 2 h. The resulting diazonium salt solution was slowly added to resorcinol (1.65 g, 15 mmol) dissolved in 50 ml of 10% sodium hydroxide solution with the reaction temperature was maintained below 0 C. The solution was stirred for 2 h and stood for 30 min to allow the precipitate to settle. The precipitate was filtered and washed several times with water until the filtrate was neutral. The product was finally purified by column chromatography over SiO2 with benzene and ethyl acetate (1:1) as an eluate to give 1.75 g (45% yield) of a., 121-66-4

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Article; Kariduraganavar; Tambe; Tasaganva; Kittur; Kulkarni; Inamdar; Journal of Molecular Structure; vol. 987; 1-3; (2011); p. 158 – 165;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-60-7,2-Methylthiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

A solution of 2-methylthiazole-5-carbaldehyde (1 g, 7.86 mmol) and ethyl 2-azidoacetate (30% in DCM, 15.8 ml_, 31 .5 mmol) was added dropwise to a solution of NaOEt (21 % in EtOH, 1 1 .7 ml_, 31 .5 mmol) and EtOH (40 ml.) at 0. After stirring for 1 hour at 0C, the temperature was allowed to come to RT and the stirring was continued for another hour. The mixture was quenched with a saturated solution of NH4CI and extracted with Et20. The organic extract was dried over Na2S04, filtered and evaporated. Purification by column chromatography on silica gel using cyclohexane and EtOAc (from 0% to 30%) provided the title compound as brown solid. 1 H NMR (400 MHz, DMSO-d6) d (ppm) 8.07 (d, 1 H), 7.27 (d, 1 H), 4.31 (q, 2H), 2.69 (s, 3H), 1 .32 (t, 3H). LC-MS: Rt = 1 .05 min; MS m/z [M+H]+ 239.1

1003-60-7, As the paragraph descriping shows that 1003-60-7 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; FARADY, Christopher; GOMMERMANN, Nina; JANSER, Philipp; MACKAY, Angela; MATTES, Henri; STIEFL, Nikolaus Johannes; VELCICKY, Juraj; (148 pag.)WO2020/21447; (2020); A1;,
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Thiazole | chemical compound | Britannica

6633-61-0,6633-61-0, Methyl 2-aminothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE I Preparation of Methyl 2-chlorothiazole-5-carboxylate To 5.0 g of methyl 2-aminothiazole-5-carboxylate [H. E. Faith, U.S. Pat. No. 2,405,820(1946)] suspended in 54 ml of 6 N hydrochloric acid stirred at-5-0 was added dropwise over 15 minutes 3.7 g of sodium nitrite dissolved in 10 ml of water. After stirring 5 minutes, the brown suspension was added in one portion to a rapidly stirred suspension of 10.6 g of cupric sulfate and 10.6 g of sodium chloride cooled at 5. The cooling bath was removed and stirring was continued for 30 minutes. The pH was adjusted to 7.3 with 6 N sodium hydroxide and the green suspension was filtered through Celite. The solid was washed with three portions of ethyl acetate and the extract was combined with the ethyl acetate extract of the original filtrate. After drying the combined extract over magnesium sulfate, concentration in vacuo gave a brown solid. Trituration with four portions of hot petroleum ether (35-60) served to separate the soluble product from some starting material. Concentration in vacuo of the petroleum ether solution gave 3.9 g. of pure methyl 2-chlorothiazole-5-carboxylate having a melting point of 41-46.

The synthetic route of 6633-61-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffmann-La Roche Inc.; US4168380; (1979); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32137-76-1,Ethyl 1,3-benzothiazole-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: Ethyl benzothiazole-2-carboxylate 4a (1 mmol) was taken in around bottom flask (10 mL). To it the aliphatic amine (4 equiv.) wasadded in excess along with (50 mg) of NH4Cl. The reaction mixturewas heated at 150 C for 2e3 h under magnetic stirring. Aftercompletion of reaction (TLC), the mixture was diluted using EtOAc,washed with1N HCl and brine, dried over anhydrous MgSO4 andconcentrated under reduced pressure to furnish the final productthat was then washed with cooled hexane.

32137-76-1, The synthetic route of 32137-76-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ghonim, Aya E.; Ligresti, Alessia; Rabbito, Alessandro; Mahmoud, Ali Mokhtar; Di Marzo, Vincenzo; Osman, Noha A.; Abadi, Ashraf H.; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 154 – 170;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1826-11-5,2-Phenylthiazole,as a common compound, the synthetic route is as follows.

4.3.1.6 2-Phenylthiazole 11 Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 1a (4.4 mg) gave [2′,6′-2H2]-11 (12.2 mg, 89%, 82%D). Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 1b (4.6 mg) gave [2′,6′-2H2]-11 (11.0 mg, 80%, 44%D). Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 1c (3.8 mg) gave [2′,6′-2H2]-11 (13.6 mg, 98%, 72%D). Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 5 (3.4 mg) gave [2′,6′-2H2]-11 (10.8 mg, 78%, 59%D). deltaH (300 MHz, DMSO-d6) 7.97-7.93 (m, 3H), 7.78 (d, 1H, J=3.3 Hz), 7.54-7.48 (m, 3H).

1826-11-5, As the paragraph descriping shows that 1826-11-5 is playing an increasingly important role.

Reference£º
Article; Atzrodt, Jens; Derdau, Volker; Kerr, William J.; Reid, Marc; Rojahn, Patrick; Weck, Remo; Tetrahedron; vol. 71; 13; (2015); p. 1924 – 1929;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66947-92-0,Methyl 2-amino-1,3-benzothiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred mixture of VIII-2 (600 mg, 2.28 mmol) and CuBr2 (775 mg, 3.46 mmol) in MeCN (9 mL) was added tert-butyl nitrite (445 mg, 4.32 mmol). The reaction mixture was stirred at rt overnight. The mixture was diluted with EtOAc (40 mL), washed with water and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by column (PE:EA=5:1) to give VIII-3 (140 mg, yield: 18%)., 66947-92-0

As the paragraph descriping shows that 66947-92-0 is playing an increasingly important role.

Reference£º
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/200215; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica